Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 11/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 11/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.38 |
| ▸ | REN | P00797 | 6/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3881258 | 0.89 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3REN | |
| SCHEMBL5320483 | 0.87 | HTR2A (0.36) | SLC6A2SLC6A4SLC6A3RENCYP2D6 | |
| SCHEMBL5593301 | 0.84 | SLC6A2 (0.35) | SLC6A2SLC6A4RENKCNH2CYP2D6 | |
| SCHEMBL5592047 | 0.84 | REN (0.34) | SLC6A2SLC6A4SLC6A3REN | |
| SCHEMBL5593634 | 0.79 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3RENKCNH2 | |
| SCHEMBL5593564 | 0.79 | SLC6A2 (0.34) | SLC6A2SLC6A4SLC6A3REN | |
| SCHEMBL5613173 | 0.78 | SLC6A2 (0.36) | SLC6A2SLC6A4SLC6A3REN | |
| SCHEMBL4754589 | 0.77 | REN (0.41) | SLC6A2SLC6A4SLC6A3RENKCNH2 | |
| SCHEMBL4755799 | 0.77 | REN (0.41) | SLC6A2SLC6A4SLC6A3RENKCNH2 | |
| SCHEMBL5612896 | 0.73 | REN (0.33) | SLC6A2SLC6A4SLC6A3RENKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010488-A2 | RENIN INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007117559-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |
| WO-2007117560-A2 | PIPERIDINE AND MORPHOLINE RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |