Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.35 |
| ▸ | ACP1 | P24666 | 1/20 | 0.35 |
| ▸ | REN | P00797 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 4/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK7 | P50613 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | CCNH | P51946 | 1/20 | 0.33 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5592047 | 0.85 | REN (0.34) | SLC6A2SLC6A4RENHTR2ACCNT1 | |
| SCHEMBL3879197 | 0.84 | SLC6A2 (0.38) | SLC6A2SLC6A4RENCYP2D6KCNH2 | |
| SCHEMBL3881258 | 0.84 | SLC6A2 (0.39) | SLC6A2SLC6A4REN | |
| SCHEMBL5320483 | 0.82 | HTR2A (0.36) | SLC6A2SLC6A4RENHTR2ACYP2D6 | |
| SCHEMBL5593564 | 0.80 | SLC6A2 (0.34) | SLC6A2SLC6A4REN | |
| SCHEMBL5613173 | 0.79 | SLC6A2 (0.36) | SLC6A2SLC6A4RENHTR2ACCNT1 | |
| SCHEMBL4754589 | 0.78 | REN (0.41) | SLC6A2SLC6A4ACP1RENCYP2D6 | |
| SCHEMBL4755799 | 0.78 | REN (0.41) | SLC6A2SLC6A4ACP1RENCYP2D6 | |
| SCHEMBL5593634 | 0.78 | SLC6A2 (0.41) | SLC6A2SLC6A4RENCYP2D6KCNH2 | |
| SCHEMBL3941676 | 0.75 | REN (0.33) | SLC6A2SLC6A4REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007117560-A2 | PIPERIDINE AND MORPHOLINE RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |