Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | ATAD2 | Q6PL18 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NCF1 | P14598 | 2/20 | 0.43 |
| ▸ | TOP2A | P11388 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15956333 | 0.84 | CYP2C19 (0.47) | BRD4ATAD2MAPTNCF1CYP2C19 | |
| SCHEMBL27681062 | 0.80 | IDO1 (0.51) | TP53GAAMAPTMAPK1HSD17B10 | |
| SCHEMBL29442601 | 0.80 | MAPT (0.47) | BRD4TP53GAAMAPTMAPK1 | |
| SCHEMBL453906 | 0.80 | MAPT (0.47) | BRD4TP53GAAMAPTMAPK1 | |
| SCHEMBL5809523 | 0.77 | MAPT (0.47) | BRD4TP53GAAMAPTMAPK1 | |
| SCHEMBL5514754 | 0.76 | MAPT (0.44) | TP53GAAMAPTMAPK1HSD17B10 | |
| SCHEMBL3194480 | 0.76 | MAPT (0.50) | TP53GAAMAPTMAPK1HSD17B10 | |
| SCHEMBL3879346 | 0.75 | MAPK1 (0.46) | TP53GAAMAPTMAPK1HSD17B10 | |
| SCHEMBL10803538 | 0.74 | MAPT (0.69) | BRD4ATAD2GAAMAPTNCF1 | |
| SCHEMBL9273078 | 0.74 | MAPT (0.45) | TP53GAAMAPTMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589127-B2 | Aminoalkylphenols, methods of using and making the same | MERCK & CO., INC. (US) | 2009-09-15 | — | — | US | disclosed |
| US-20050234265-A1 | Aminoalkylphenols, methods of using and making the same | MERCK SHARP & DOHME LLC | 2005-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234265-A1 | Aminoalkylphenols, methods of using and making the same | NPEPPS, PHOSPHO1, LNPEP | BRD4 1150/4885ATAD2 1940/4885TP53 3650/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.