Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.38 |
| ▸ | RBP4 | P02753 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | UBE2M | P61081 | 6/20 | 0.37 |
| ▸ | DCUN1D1 | Q96GG9 | 6/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3877923 | 0.86 | GRM5 (0.44) | ALDH1A1CYP2C9CYP2C19GAAUBE2M | |
| SCHEMBL3878904 | 0.85 | UBE2M (0.36) | ALDH1A1CYP2C9CYP2C19UBE2MDCUN1D1 | |
| SCHEMBL3881846 | 0.85 | DRD3 (0.40) | ALDH1A1UBE2MDCUN1D1LMNATP53 | |
| SCHEMBL3879032 | 0.85 | PDE5A (0.38) | EPHX2ALDH1A1CYP2C9CYP2C19UBE2M | |
| SCHEMBL3879091 | 0.85 | UBE2M (0.41) | SMN1; SMN2ALDH1A1CYP2D6CYP2C9SLC9A1 | |
| SCHEMBL3882222 | 0.84 | ALDH1A1 (0.38) | SMN1; SMN2ALDH1A1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL3885757 | 0.83 | GRM5 (0.37) | ALDH1A1UBE2MDCUN1D1LMNAPOLB | |
| SCHEMBL3880223 | 0.83 | UBE2M (0.43) | ALDH1A1CYP2C9CYP2C19GAAUBE2M | |
| SCHEMBL3882841 | 0.83 | UBE2M (0.33) | ALDH1A1CYP2C9CYP2C19GAAUBE2M | |
| SCHEMBL3879769 | 0.83 | L3MBTL1 (0.45) | L3MBTL1EPHX2SMN1; SMN2ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858900-B1 | FUSED THIAZOLE DERIVATIVES HAVING AFFINITY FOR THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LTD (GB) | 2009-01-07 | — | — | EP | claimed |
| US-20080161289-A1 | Fused Thiazole Derivatives Having Affinity for the Histamine H3 Receptor | GLAXO GROUP LIMITED | 2008-07-03 | — | — | US | claimed |
| EP-1858900-B1 | FUSED THIAZOLE DERIVATIVES HAVING AFFINITY FOR THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LTD (GB) | 2009-01-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161289-A1 | Fused Thiazole Derivatives Having Affinity for the Histamine H3 Receptor | HRH3, HRH4, HRH2 | L3MBTL1 2435/4885EPHX2 499/4885SMN1; SMN2 2170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.