Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SCD5 | Q86SK9 | 2/20 | 0.39 |
| ▸ | RBP4 | P02753 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3877921 | 0.86 | GRM5 (0.46) | L3MBTL1HRH3ALDH1A1L3MBTL3CYP2C9 | |
| SCHEMBL3878900 | 0.85 | HRH3 (0.37) | L3MBTL1HRH3SMN1; SMN2ALDH1A1L3MBTL3 | |
| SCHEMBL3881839 | 0.85 | HSD11B1 (0.43) | L3MBTL1ALDH1A1L3MBTL3CYP2C9CYP2C19 | |
| SCHEMBL3879027 | 0.84 | PDE5A (0.42) | L3MBTL1SMN1; SMN2ALDH1A1L3MBTL3CYP2C9 | |
| SCHEMBL3879089 | 0.84 | KDM4E (0.51) | L3MBTL1L3MBTL3CYP2C9CYP2C19TP53 | |
| SCHEMBL3882219 | 0.83 | ALDH1A1 (0.40) | L3MBTL1SMN1; SMN2ALDH1A1L3MBTL3CYP2C9 | |
| SCHEMBL3879772 | 0.83 | L3MBTL1 (0.44) | L3MBTL1EPHX2SMN1; SMN2ALDH1A1CYP2C9 | |
| SCHEMBL3882837 | 0.83 | L3MBTL3 (0.37) | L3MBTL1HRH3ALDH1A1L3MBTL3CYP2D6 | |
| SCHEMBL3880220 | 0.83 | HSD11B1 (0.46) | L3MBTL1ALDH1A1L3MBTL3CYP2C9CYP2C19 | |
| SCHEMBL3885754 | 0.83 | POLB (0.41) | L3MBTL1HRH3ALDH1A1L3MBTL3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858900-B1 | FUSED THIAZOLE DERIVATIVES HAVING AFFINITY FOR THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LTD (GB) | 2009-01-07 | — | — | EP | claimed |
| US-20080161289-A1 | Fused Thiazole Derivatives Having Affinity for the Histamine H3 Receptor | GLAXO GROUP LIMITED | 2008-07-03 | — | — | US | claimed |
| EP-1858900-B1 | FUSED THIAZOLE DERIVATIVES HAVING AFFINITY FOR THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LTD (GB) | 2009-01-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161289-A1 | Fused Thiazole Derivatives Having Affinity for the Histamine H3 Receptor | HRH3, HRH4, HRH2 | L3MBTL1 2435/4885EPHX2 499/4885HRH3 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.