Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 2/20 | 0.36 |
| ▸ | HRH2 | P25021 | 2/20 | 0.35 |
| ▸ | HRH1 | P35367 | 2/20 | 0.35 |
| ▸ | CTSL | P07711 | 3/20 | 0.34 |
| ▸ | CTSK | P43235 | 2/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | CMA1 | P23946 | 1/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.33 |
| ▸ | PREP | P48147 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7067087 | 0.77 | ACE (0.34) | ACE | |
| SCHEMBL3885067 | 0.77 | ACE (0.48) | ACE | |
| SCHEMBL5377148 | 0.73 | ACE (0.60) | ACEMME | |
| SCHEMBL17348387 | 0.71 | ACE (0.53) | KMT2AACEHRH1KDM4EMAPT | |
| SCHEMBL6242739 | 0.71 | ACE (0.53) | KMT2AACEHRH1KDM4EMAPT | |
| SCHEMBL16000759 | 0.71 | ACE (0.53) | KMT2AACEHRH1KDM4EMAPT | |
| SCHEMBL2262901 | 0.71 | ACE (0.53) | KMT2AACEHRH1KDM4EMAPT | |
| SCHEMBL13950858 | 0.71 | ACE (0.53) | KMT2AACEHRH1KDM4EMAPT | |
| SCHEMBL5564856 | 0.70 | ACE (0.45) | ACEMME | |
| SCHEMBL19181306 | 0.70 | ACE (0.43) | ACEMME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7534896-B2 | Process for the synthesis of perindopril and its pharmaceutically acceptable salts | LES LABORATORIES SERVIER (FR) | 2009-05-19 | — | — | US | disclosed |
| US-7183308-B1 | Metod for the synthesis of perindopril and the pharmaceutically acceptable salts thereof | LES LABORATOIRES SERVIER (FR) | 2007-02-27 | — | — | US | disclosed |
| US-20070043103-A1 | NOVEL METOD FOR THE SYNTHESIS OF PERINDOPRIL AND THE PHARMACEUTICALLY-ACCEPTABLE SALTS THEREOF | LES LABORATOIRES SERVIER (FR) | 2007-02-22 | — | — | US | disclosed |
| US-20070010572-A1 | NOVEL METHOD FOR THE SYNTHESIS OF PERINDOPRIL AND THE PHARMACEUTICALLY-ACCEPTABLE SALTS THEREOF | LES LABORATOIRES SERVIER (FR) | 2007-01-11 | — | — | US | disclosed |
| EP-1380590-B1 | Method for synthesis of perindopril and its pharmaceutically acceptable salts | SERVIER LAB (FR) | 2006-09-06 | — | — | EP | disclosed |
| EP-1380591-B1 | Method for synthesis of perindopril and its pharmaceutically acceptable salts | SERVIER LAB (FR) | 2005-11-16 | — | — | EP | disclosed |
| EP-1371659-B1 | Method for synthesis of perindopril and its pharmaceutically acceptable salts [2003/26] | SERVIER LAB (FR) | 2005-10-12 | — | — | EP | disclosed |
| EP-1403277-B1 | Method for synthesis of (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indole-2-carboxylic acid derivatives and use in the synthesis of perindopril | SERVIER LAB (FR) | 2005-10-05 | — | — | EP | disclosed |
| WO-2005023842-A1 | NOVEL METHOD FOR THE SYNTHESIS OF PERINDOPRIL AND THE PHARMACEUTICALLY-ACCEPTABLE SALTS THEREOF | LES LABORATOIRES SERVIER (FR) | 2005-03-17 | — | — | WO | disclosed |
| WO-2005023843-A1 | NOVEL METHOD FOR THE SYNTHESIS OF PERINDOPRIL AND THE PHARMACEUTICALLY-ACCEPTABLE SALTS THEREOF | LES LABORATOIRES SERVIER (FR) | 2005-03-17 | — | — | WO | disclosed |
| WO-2005023841-A1 | NOVEL METHOD FOR THE SYNTHESIS OF PERINDOPRIL AND THE PHARMACEUTICALLY-ACCEPTABLE SALTS THEREOF | LES LABORATOIRES SERVIER (FR) | 2005-03-17 | — | — | WO | disclosed |
| WO-2004078708-A2 | NOVEL METHOD FOR SYNTHESISING DERIVATIVES OF (2S, 3AS, 7AS)-1-[(S)-ALANYL]-OCTAHYDRO,-IH-INDOLE-2-CARBOXYLIC ACID AND THE USE THEREOF FOR PERINDOPRIL SYNTHESIS | LES LABORATOIRES SERVIER (FR) | 2004-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043103-A1 | NOVEL METOD FOR THE SYNTHESIS OF PERINDOPRIL AND THE PHARMACEUTICALLY-ACCEPTABLE SALTS THEREOF | ACE, REN, QDPR | KMT2A 2719/4885ACE 1/4885HRH2 2955/4885 |
| US-20070010572-A1 | NOVEL METHOD FOR THE SYNTHESIS OF PERINDOPRIL AND THE PHARMACEUTICALLY-ACCEPTABLE SALTS THEREOF | ACE, QDPR, REN | KMT2A 3110/4885ACE 1/4885HRH2 2166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.