Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 1/20 | 0.42 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.42 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 5/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CCR4 | P51679 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6262440 | 0.87 | RXFP1 (0.42) | ACVR1TGFBR1HTR7HSD17B10MAPT | |
| SCHEMBL18171738 | 0.79 | ACVR1 (0.45) | ACVR1TGFBR1HTR7CCR4ADRB1 | |
| SCHEMBL6746969 | 0.75 | ACVR1 (0.41) | ACVR1TGFBR1HTR7ALDH1A1HSD17B10 | |
| SCHEMBL27675711 | 0.72 | ADRB1 (0.49) | ACVR1TGFBR1HTR7HSD17B10KDM4E | |
| SCHEMBL6389895 | 0.71 | KDM4E (0.57) | ALDH1A1HSD17B10KDM4EHPGDTSHR | |
| SCHEMBL16600110 | 0.71 | BTK (0.42) | ACVR1HTR7ALDH1A1HPGDHTR6 | |
| Hydrochloric Acid SCHEMBL31349206 | 0.71 | ADRB1 (0.47) | ACVR1TGFBR1HTR7HSD17B10KDM4E | |
| SCHEMBL1742844 | 0.71 | ADRB1 (0.59) | HTR7HSD17B10TSHRHTR6NPC1 | |
| SCHEMBL1742849 | 0.71 | ADRB1 (0.47) | ACVR1HTR7ALDH1A1KDM4ENPC1 | |
| Hydrochloric Acid SCHEMBL27844227 | 0.71 | ADRB1 (0.47) | ACVR1TGFBR1HTR7HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501513-B1 | COMPOSITIONS AND METHODS FOR COMBATING LOWER URINARY TRACT DYSFUNCTIONS WITH DELTA OPIOID RECEPTOR AGONISTS | VERSI GROUP LLC (US) | 2014-04-16 | — | — | EP | disclosed |
| EP-1395567-B1 | 4 (PHENYL-PIPERAZINYL-METHYL) BENZAMIDE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PAIN ANXIETY OR GASTROINTESTINAL DISORDERS | ASTRAZENECA AB (SE) | 2009-01-14 | — | — | EP | disclosed |
| US-6696447-B2 | ANALGESICS; GASTROINTESTINAL DISORDERS | ASTRAZENECA AB (SE) | 2004-02-24 | — | — | US | disclosed |
| US-20030139421-A1 | Hydroxyphenyl-piperazinyl-methyl-benzamide derivatives for the treatment of pain | ASTRAZENECA AB (SE) | 2003-07-24 | — | — | US | disclosed |
| CN-1422266-A | Hydroxyphenyl-piperazinyl-methyl-benzamide derivatives for the treatment of pain | ASTRAZENECA AB (SE) | 2003-06-04 | — | — | CN | disclosed |
| CN-1422266-A | Hydroxyphenyl-piperazinyl-methyl-benzamide derivatives for the treatment of pain | ASTRAZENECA AB (SE) | 2003-06-04 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030139421-A1 | Hydroxyphenyl-piperazinyl-methyl-benzamide derivatives for the treatment of pain | OPRM1, OPRK1, PTGER1 | SMARCA2 3914/4885SMARCA4 4219/4885PBRM1 462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.