Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | STS | P08842 | 1/20 | 0.46 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1865498 | 1.00 | POLB (0.53) | POLBMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL970360 | 0.85 | POLB (0.51) | POLBMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL970359 | 0.85 | POLB (0.51) | POLBMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL1865320 | 0.84 | HSD11B1 (0.52) | POLBMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL12991579 | 0.84 | ALDH1A1 (0.51) | POLBMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL5593571 | 0.83 | RAB9A (0.53) | POLBMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL1861675 | 0.83 | RAB9A (0.53) | POLBMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL31358021 | 0.83 | ALDH1A1 (0.53) | POLBMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL1870934 | 0.82 | GAA (0.48) | POLBMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL2328635 | 0.80 | ALDH1A1 (0.51) | MEN1KMT2AALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010488-A2 | RENIN INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007117559-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |