Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.60 |
| ▸ | TSHR | P16473 | 3/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.55 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.52 |
| ▸ | GALR2 | O43603 | 1/20 | 0.49 |
| ▸ | GALR1 | P47211 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3878287 | 0.92 | GALR2 (0.58) | CYP1A2CYP2C19CYP2C9CYP3A4TSHR | |
| SCHEMBL3876551 | 0.91 | GALR2 (0.59) | CYP1A2CYP2C19CYP2C9CYP3A4TSHR | |
| SCHEMBL3876846 | 0.88 | MTOR (0.49) | L3MBTL1PIK3CAGALR2GALR1HSD11B1 | |
| SCHEMBL3878776 | 0.88 | CYP1A2 (0.64) | CYP1A2CYP2C19CYP2C9CYP3A4TSHR | |
| SCHEMBL3877598 | 0.88 | CYP1A2 (0.54) | CYP1A2CYP2C19CYP2C9CYP3A4TSHR | |
| SCHEMBL3876757 | 0.87 | MTOR (0.53) | L3MBTL1PIK3CATRPA1HSD11B1TDP1 | |
| SCHEMBL3878211 | 0.87 | NPSR1 (0.57) | L3MBTL1HSD11B1TDP1MTORTRPV1 | |
| SCHEMBL3882297 | 0.86 | NPSR1 (0.54) | L3MBTL1HSD11B1TDP1MTORTRPV1 | |
| SCHEMBL3877647 | 0.86 | HSD11B1 (0.52) | L3MBTL1PIK3CATRPA1HSD11B1TDP1 | |
| SCHEMBL3878102 | 0.85 | MTOR (0.47) | L3MBTL1PIK3CATRPA1HSD11B1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | claimed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-20070027155-A1 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION | 2007-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027155-A1 | Biaryl piperazinyl-pyridine analogues | GPR174, GPR68, PPARG | CYP1A2 405/4885CYP2C19 648/4885CYP2C9 1234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.