SCHEMBL3885149

SCHEMBL3885149

COc1cc(N)c(C(=O)Nc2ccc(CCN3CCc4cc(OC)c(OC)cc4C3)cc2)cc1OC

nearest known ligand 0.83

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ABCB1 P08183 20/20 0.83
ABCG2 Q9UNQ0 18/20 0.83

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17653795 0.95 ABCB1 (0.76) ABCB1ABCG2
SCHEMBL4040317 0.92 ABCB1 (0.82) ABCB1ABCG2
SCHEMBL7173150 0.91 ABCG2 (0.80) ABCB1ABCG2
SCHEMBL4040133 0.91 ABCB1 (0.80) ABCB1ABCG2
SCHEMBL7168625 0.91 ABCB1 (0.80) ABCB1ABCG2
SCHEMBL4048100 0.91 ABCB1 (0.80) ABCB1ABCG2
SCHEMBL3885917 0.91 ABCB1 (1.00) ABCB1ABCG2
SCHEMBL3885147 0.90 ABCB1 (0.77) ABCB1ABCG2
SCHEMBL4041965 0.90 ABCB1 (0.76) ABCB1ABCG2
SCHEMBL4045322 0.90 ABCB1 (0.79) ABCB1ABCG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7524861-B2 Process for the preparation of a hydrate of an anthranilic acid derivative XENOVA LIMITED (GB) 2009-04-28 US claimed
EP-1506188-B1 PROCESS FOR THE PREPARATION OF A HYDRATE OF AN ANTHRANILIC ACID DERIVATIVE XENOVA LTD (GB) 2009-02-25 EP claimed
US-20050222199-A1 Process for the preparation of a hydrate of an antranilic acid derivative XENOVA LIMITED (GB) 2005-10-06 US claimed
EP-1506188-A1 PROCESS FOR THE PREPARATION OF A HYDRATE OF AN ANTHRANILIC ACID DERIVATIVE Xenova Limited (GB) 2005-02-16 EP claimed
EP-0934276-B1 ANTHRANILIC ACID DERIVATIVES AS MULTI DRUG RESISTANCE MODULATORS XENOVA LTD (GB) 2003-12-17 EP claimed
WO-2003095447-A1 PROCESS FOR THE PREPARATION OF A HYDRATE OF AN ANTHRANILIC ACID DERIVATIVE XENOVA LIMITED (GB) 2003-11-20 WO claimed
US-6218393-B1 IN THERAPY OF MULTIDRUG RESISTANT CANCERS, FOR EXAMPLE TO POTENTIATE CYTOTOXICITY OF CANCER DRUG XENOVA LIMITED (GB) 2001-04-17 US claimed
US-20190343827-A1 DEUTERATED ANALOGS OF TARIQUIDAR IZUMI TECHNOLOGY, LLC (US) 2019-11-14 US disclosed
US-20190343827-A1 DEUTERATED ANALOGS OF TARIQUIDAR IZUMI TECHNOLOGY, LLC (US) 2019-11-14 US disclosed
US-7524861-B2 Process for the preparation of a hydrate of an anthranilic acid derivative XENOVA LIMITED (GB) 2009-04-28 US disclosed
EP-1506188-B1 PROCESS FOR THE PREPARATION OF A HYDRATE OF AN ANTHRANILIC ACID DERIVATIVE XENOVA LTD (GB) 2009-02-25 EP disclosed
EP-1711490-A4 NOVEL P-GLYCOPROTEIN INHIBITOR, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME HANMI PHARM IND CO LTD (KR) 2007-04-04 EP disclosed
EP-1711490-A1 NOVEL P-GLYCOPROTEIN INHIBITOR, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME Hanmi Pharm. Co., Ltd. (KR) 2006-10-18 EP disclosed
US-20050222199-A1 Process for the preparation of a hydrate of an antranilic acid derivative XENOVA LIMITED (GB) 2005-10-06 US disclosed
WO-2005033101-A1 NOVEL P-GLYCOPROTEIN INHIBITOR, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME HANMI PHARM. CO., LTD. (KR) 2005-04-14 WO disclosed
EP-1506188-A1 PROCESS FOR THE PREPARATION OF A HYDRATE OF AN ANTHRANILIC ACID DERIVATIVE Xenova Limited (GB) 2005-02-16 EP disclosed
WO-2003095447-A1 PROCESS FOR THE PREPARATION OF A HYDRATE OF AN ANTHRANILIC ACID DERIVATIVE XENOVA LIMITED (GB) 2003-11-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190343827-A1 DEUTERATED ANALOGS OF TARIQUIDAR ABCG2, ABCB11, ALPP ABCB1 4/4885ABCG2 1/4885
US-20050222199-A1 Process for the preparation of a hydrate of an antranilic acid derivative H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, FHIT, ATIC ABCB1 647/4885ABCG2 8/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.