SCHEMBL3885497

SCHEMBL3885497

Cc1cc(NC(=O)CN2CCOCC2)cc(C)c1O

nearest known ligand 0.73

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.61
SMN1; SMN2 Q16637 1/20 0.61
ALDH1A1 P00352 8/20 0.59
ATM Q13315 1/20 0.58
HPGD P15428 1/20 0.57
ALOX15 P16050 1/20 0.57
HTT P42858 1/20 0.56
RAB9A P51151 1/20 0.56
MEN1 O00255 1/20 0.55
POLB P06746 1/20 0.55
KMT2A Q03164 1/20 0.55
GAA P10253 1/20 0.55
NPSR1 Q6W5P4 1/20 0.55
MAPK1 P28482 1/20 0.55
L3MBTL1 Q9Y468 1/20 0.55
KDM4E B2RXH2 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL3886305 0.99 LMNA (0.59) LMNASMN1; SMN2ALDH1A1ATMHPGD
SCHEMBL3885073 0.86 RAB9A (0.76) LMNAATMHPGDALOX15HTT
Hydrochloric Acid SCHEMBL3889023 0.85 RAB9A (0.74) LMNAATMHPGDALOX15HTT
SCHEMBL23962395 0.82 ATM (0.57) LMNASMN1; SMN2ALDH1A1ATMHPGD
SCHEMBL12618600 0.82 ALDH1A1 (0.68) LMNASMN1; SMN2ALDH1A1ATMHPGD
SCHEMBL9921691 0.81 ATM (0.76) LMNASMN1; SMN2ALDH1A1ATMHPGD
SCHEMBL24849177 0.80 MEN1 (0.59) LMNASMN1; SMN2ALDH1A1ATMHPGD
SCHEMBL15587778 0.80 ATM (0.65) LMNASMN1; SMN2ALDH1A1ATMHPGD
SCHEMBL13597049 0.80 ALDH1A1 (0.77) LMNASMN1; SMN2ALDH1A1ATMHPGD
SCHEMBL25526991 0.79 LMNA (0.64) LMNASMN1; SMN2ALDH1A1ATMHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090137593-A1 4-AMINO-2,6-DIMETHYLPHENOL COMPOUND, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME AZIEN CHIM RIUNITE ANGEL FRANC A.C.R.A.F. S.P.A. (IT) 2009-05-28 US disclosed
US-20090137593-A1 4-AMINO-2,6-DIMETHYLPHENOL COMPOUND, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME AZIEN CHIM RIUNITE ANGEL FRANC A.C.R.A.F. S.P.A. (IT) 2009-05-28 US disclosed
US-20090137593-A1 4-AMINO-2,6-DIMETHYLPHENOL COMPOUND, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME AZIEN CHIM RIUNITE ANGEL FRANC A.C.R.A.F. S.P.A. (IT) 2009-05-28 US disclosed
EP-2013192-A1 4-AMINO-2,6-DIMETHYLPHENOL COMPOUND, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. (IT) 2009-01-14 EP disclosed
WO-2007124832-A1 4-AMINO-2,6-DIMETHYLPHENOL COMPOUND, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) 2007-11-08 WO disclosed
WO-2007124832-A1 4-AMINO-2,6-DIMETHYLPHENOL COMPOUND, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) 2007-11-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090137593-A1 4-AMINO-2,6-DIMETHYLPHENOL COMPOUND, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME DNPEP, MPHOSPH6, AASDHPPT LMNA 2973/4885SMN1; SMN2 2993/4885ALDH1A1 2065/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.