Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CCR1 | P32246 | 2/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3892280 | 0.81 | IMPDH2 (0.38) | IMPDH2ALDH1A1FSCN1PSEN1PSEN2 | |
| SCHEMBL3949385 | 0.73 | HSD11B1 (0.56) | — | |
| SCHEMBL350146 | 0.70 | HSD11B1 (0.56) | ALDH1A1 | |
| SCHEMBL3883604 | 0.68 | FSCN1 (0.50) | ALDH1A1FSCN1PSEN1PSEN2APH1B | |
| SCHEMBL14342735 | 0.65 | AVPR1A (0.36) | ALDH1A1FSCN1KDM4ESIRT2NPC1 | |
| SCHEMBL3883579 | 0.65 | NPC1 (0.50) | ALDH1A1SMN1; SMN2TP53NPC1LMNA | |
| SCHEMBL3884642 | 0.65 | KMT2A (0.38) | ALDH1A1FSCN1SIRT2PROKR1EPHX2 | |
| SCHEMBL3950706 | 0.65 | AVPR1A (0.49) | ALDH1A1KDM4ENPC1LMNAPOLB | |
| SCHEMBL14387302 | 0.64 | FSCN1 (0.38) | ALDH1A1FSCN1KDM4ETP53SIRT2 | |
| SCHEMBL3955052 | 0.62 | AHR (0.40) | FSCN1PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013163-A1 | TETRASUBSTITUTED UREAS AS MODULATORS OF 11-BETA HYDROXYL STEROID DEHYDROGENASE TYPE 1 | Incyte Corporation (US) | 2009-01-14 | — | — | EP | claimed |
| US-20070293529-A1 | Tetrasubstituted ureas as modulators of 11-beta hydroxyl steroid dehydrogenase type 1 | INCYTE CORPORATION | 2007-12-20 | — | — | US | claimed |
| WO-2007130898-A1 | TETRASUBSTITUTED UREAS AS MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1 | INCYTE CORPORATION (US) | 2007-11-15 | — | — | WO | claimed |
| EP-2013163-A1 | TETRASUBSTITUTED UREAS AS MODULATORS OF 11-BETA HYDROXYL STEROID DEHYDROGENASE TYPE 1 | Incyte Corporation (US) | 2009-01-14 | — | — | EP | disclosed |
| US-20070293529-A1 | Tetrasubstituted ureas as modulators of 11-beta hydroxyl steroid dehydrogenase type 1 | INCYTE CORPORATION | 2007-12-20 | — | — | US | disclosed |
| US-20070293529-A1 | Tetrasubstituted ureas as modulators of 11-beta hydroxyl steroid dehydrogenase type 1 | INCYTE CORPORATION | 2007-12-20 | — | — | US | disclosed |
| WO-2007130898-A1 | TETRASUBSTITUTED UREAS AS MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1 | INCYTE CORPORATION (US) | 2007-11-15 | — | — | WO | disclosed |
| WO-2007130898-A1 | TETRASUBSTITUTED UREAS AS MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1 | INCYTE CORPORATION (US) | 2007-11-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293529-A1 | Tetrasubstituted ureas as modulators of 11-beta hydroxyl steroid dehydrogenase type 1 | HSD11B1, HSD17B1, HSD17B11 | IMPDH2 254/4885ALDH1A1 131/4885FSCN1 4269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.