Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11538337 | 0.87 | FSCN1 (0.54) | AHRMAPTFSCN1THRBIDO1 | |
| Iodide SCHEMBL3955556 | 0.75 | LMNA (0.43) | SIRT2FSCN1THRBKMT2APROKR1 | |
| SCHEMBL11542419 | 0.74 | AHR (0.50) | AHRMAPTFSCN1THRBCYP3A4 | |
| SCHEMBL3883604 | 0.73 | FSCN1 (0.50) | MAPTSIRT2FSCN1KMT2APSEN1 | |
| SCHEMBL11540763 | 0.72 | AHR (0.56) | AHRMAPTFSCN1THRBKMT2A | |
| SCHEMBL11540118 | 0.70 | AHR (0.46) | AHRMAPTTHRBKMT2APSEN1 | |
| SCHEMBL11540399 | 0.70 | AHR (0.51) | AHRMAPTFSCN1THRBPSEN1 | |
| SCHEMBL19691848 | 0.69 | ALDH1A1 (0.50) | AHRMAPTCYP3A4CYP2D6 | |
| SCHEMBL14387302 | 0.69 | FSCN1 (0.38) | SIRT2FSCN1KMT2AIDO1PROKR1 | |
| SCHEMBL11541542 | 0.69 | MAPT (0.45) | AHRMAPTKMT2AIDO1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013163-A1 | TETRASUBSTITUTED UREAS AS MODULATORS OF 11-BETA HYDROXYL STEROID DEHYDROGENASE TYPE 1 | Incyte Corporation (US) | 2009-01-14 | — | — | EP | disclosed |
| US-20070293529-A1 | Tetrasubstituted ureas as modulators of 11-beta hydroxyl steroid dehydrogenase type 1 | INCYTE CORPORATION | 2007-12-20 | — | — | US | disclosed |
| WO-2007130898-A1 | TETRASUBSTITUTED UREAS AS MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1 | INCYTE CORPORATION (US) | 2007-11-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293529-A1 | Tetrasubstituted ureas as modulators of 11-beta hydroxyl steroid dehydrogenase type 1 | HSD11B1, HSD17B1, HSD17B11 | AHR 2026/4885MAPT 1541/4885SIRT2 2871/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.