Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 1/20 | 0.82 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.82 |
| ▸ | ITGAL | P20701 | 1/20 | 0.82 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | CRHBP | P24387 | 2/20 | 0.70 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.70 |
| ▸ | HTT | P42858 | 1/20 | 0.70 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11519392 | 0.91 | ITGB2 (1.00) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL27796077 | 0.91 | ITGB2 (1.00) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL8518 | 0.91 | ITGB2 (1.00) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL6791411 | 0.91 | ITGB2 (1.00) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL11406989 | 0.91 | ITGB2 (1.00) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL11399163 | 0.91 | ITGB2 (1.00) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL29997436 | 0.91 | ITGB2 (1.00) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| Methyl Alcohol SCHEMBL3885106 | 0.88 | ITGB2 (0.82) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| Bromomethane SCHEMBL3888151 | 0.88 | ITGB2 (0.82) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| Methane SCHEMBL28630381 | 0.88 | ITGB2 (0.93) | ITGB2ICAM1ITGALSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 187 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0520674-B1 | Antipsychotic benzodioxan derivatives | AMERICAN HOME PROD (US) | 1995-08-16 | — | — | EP | claimed |
| EP-0658160-A1 | ANTIPSYCHOTIC QUINOLINE DERIVATIVES OF BENZODIOXANMETHYLAMINE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-06-21 | — | — | EP | claimed |
| WO-1994005655-A1 | ANTIPSYCHOTIC QUINOLINE DERIVATIVES OF BENZODIOXANMETHYLAMINE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-03-17 | — | — | WO | claimed |
| US-5245051-A | Antipsychotic chroman derivatives of benzodioxanmethylamine | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-09-14 | — | — | US | claimed |
| US-5235055-A | Antipsychotic quinoline derivatives of benzodioxanmethylamine | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-08-10 | — | — | US | claimed |
| EP-0520674-A1 | Antipsychotic benzodioxan derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-12-30 | — | — | EP | claimed |
| US-5166367-A | Anxiolytic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-11-24 | — | — | US | claimed |
| US-5126366-A | Antidepressants, antipsychotics, anxiolytic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-06-30 | — | — | US | claimed |
| CN-102036976-B | Modulators of dopamine neurotransmission | NSAB AF NEUROSEARCH SWEDEN AB | 2013-05-01 | — | — | CN | disclosed |
| CN-102036976-A | Modulators of dopamine neurotransmission | NSAB AF NEUROSEARCH SWEDEN AB | 2011-04-27 | — | — | CN | disclosed |
| US-20090042895-A1 | Antidepressant Piperidine Derivatives of Heterocycle-Fused Benzodioxans | WYETH (US) | 2009-02-12 | — | — | US | disclosed |
| US-7488751-B2 | Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan | WYETH (US) | 2009-02-10 | — | — | US | disclosed |
| US-7479500-B2 | Antidepressant piperidine derivatives of heterocyclefused benzodioxans | WYETH (US) | 2009-01-20 | — | — | US | disclosed |
| US-7419986-B2 | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans | WYETH (US) | 2008-09-02 | — | — | US | disclosed |
| US-5182292-A | Psychotropic piperidinylmethyl benzodioxans | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-01-26 | — | — | US | disclosed |
| EP-0520674-A1 | Antipsychotic benzodioxan derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-12-30 | — | — | EP | disclosed |
| US-5166367-A | Anxiolytic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-11-24 | — | — | US | disclosed |
| US-5134140-A | Psychotropic benzofuran derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-07-28 | — | — | US | disclosed |
| US-5126366-A | Antidepressants, antipsychotics, anxiolytic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-06-30 | — | — | US | disclosed |
| US-5126367-A | Antipsychotic, anxiolytic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042895-A1 | Antidepressant Piperidine Derivatives of Heterocycle-Fused Benzodioxans | HTR5A, OPRD1, CRH | ITGB2 2528/4885ICAM1 3063/4885ITGAL 2718/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.