Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 2/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | KCNJ6 | P48051 | 2/20 | 0.33 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 3/20 | 0.32 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
| ▸ | JAK1 | P23458 | 2/20 | 0.31 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.31 |
| ▸ | EEF2K | O00418 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3492314 | 1.00 | HPGDS (0.34) | HPGDSBACE1BACE2GRM5GRM1 | |
| SCHEMBL13435140 | 0.89 | PDK1 (0.38) | BACE1TP53CDK9RORCJAK2 | |
| SCHEMBL4249026 | 0.86 | KCNJ6 (0.35) | BACE1BACE2KCNJ6KCNJ3KCNJ5 | |
| SCHEMBL3479619 | 0.86 | KCNJ6 (0.35) | BACE1BACE2KCNJ6KCNJ3KCNJ5 | |
| SCHEMBL13435142 | 0.84 | OPRM1 (0.37) | HPGDSBACE1BACE2EEF2K | |
| SCHEMBL13435141 | 0.84 | HPGDS (0.35) | HPGDSBACE1BACE2GRM5GRM1 | |
| SCHEMBL5326122 | 0.82 | ADORA3 (0.39) | BACE1BACE2 | |
| SCHEMBL3479516 | 0.81 | MAPK14 (0.39) | BACE1BACE2KCNJ6KCNJ3KCNJ5 | |
| SCHEMBL3893080 | 0.81 | MAPK14 (0.39) | BACE1BACE2KCNJ6KCNJ3KCNJ5 | |
| SCHEMBL5616430 | 0.80 | BACE1 (0.35) | BACE1BACE2KCNJ6KCNJ3KCNJ5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091328-A2 | SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | Merck & Co., Inc. (US) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008054698-A2 | SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK & CO., INC. (US) | 2008-05-08 | — | — | WO | disclosed |