Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.59 |
| ▸ | CCKBR | P32239 | 1/20 | 0.53 |
| ▸ | CALCRL | Q16602 | 14/20 | 0.52 |
| ▸ | RAMP1 | O60894 | 2/20 | 0.49 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9423126 | 0.84 | CCKBR (0.74) | CCKBR | |
| SCHEMBL9422961 | 0.84 | CCKBR (0.74) | CCKBR | |
| SCHEMBL9422957 | 0.84 | CCKBR (0.74) | CCKBR | |
| SCHEMBL4410860 | 0.80 | KCNH2 (0.54) | KCNH2CCKBRSENP1 | |
| SCHEMBL8223082 | 0.78 | KCNH2 (0.73) | KCNH2CALCRLRAMP1 | |
| SCHEMBL3252895 | 0.77 | KCNH2 (0.47) | KCNH2CCKBRCALCRLRAMP1 | |
| SCHEMBL4413834 | 0.76 | SENP1 (0.56) | CCKBRSENP1 | |
| SCHEMBL9866235 | 0.76 | CCKBR (0.59) | CCKBR | |
| SCHEMBL7212286 | 0.75 | KCNH2 (0.64) | KCNH2CCKBRCALCRLRAMP1 | |
| SCHEMBL9256656 | 0.75 | CCKBR (0.40) | CCKBRSENP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856100-A4 | CGRP RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2009-04-15 | — | — | EP | disclosed |
| EP-1856100-A2 | CGRP RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006078554-A2 | CGRP RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2006-07-27 | — | — | WO | disclosed |