Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | NT5C2 | P49902 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3877942 | 0.80 | SMN1; SMN2 (0.38) | NPC1RAB9AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8121389 | 0.76 | BRD4 (0.51) | BRD4PDPK1NT5C2ADORA3NT5E | |
| SCHEMBL27703108 | 0.75 | PARP1 (0.41) | CCNB2CCNE2CDK1CCNB1CCNE1 | |
| SCHEMBL2514195 | 0.72 | BRD4 (0.47) | BRD4PDPK1NT5C2HDAC6ADORA3 | |
| SCHEMBL159109 | 0.71 | ADORA2A (0.40) | CCNB2CDK1CCNB1CDK2CCNB3 | |
| SCHEMBL23123 | 0.71 | BRD4 (0.64) | BRD4PDPK1NPC1RAB9ANT5C2 | |
| SCHEMBL6463473 | 0.70 | BRD4 (0.60) | BRD4PDPK1NPC1RAB9ANT5C2 | |
| SCHEMBL8381773 | 0.70 | BRD4 (0.63) | BRD4PDPK1NPC1RAB9ANT5C2 | |
| SCHEMBL7717445 | 0.69 | BRD4 (0.51) | BRD4CDK2PDPK1NPC1RAB9A | |
| SCHEMBL11023230 | 0.67 | BRD4 (0.52) | BRD4PDPK1NPC1RAB9ANT5C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090118220-A1 | SUBSTITUTED ADENINES AND THE USES THEREOF | ASTRAZENECA AB (SE) | 2009-05-07 | — | — | US | disclosed |
| CN-101410407-A | Substituted adenines and the uses thereof | ASTRAZENECA AB (SE) | 2009-04-15 | — | — | CN | disclosed |
| US-20090048203-A1 | SUBSTITUTED ADENINES AND THE USES THEREOF | ASTRAZENECA AB (SE) | 2009-02-19 | — | — | US | disclosed |
| EP-2010553-A1 | SUBSTITUTED ADENINES AND THE USES THEREOF | AstraZeneca AB (SE) | 2009-01-07 | — | — | EP | disclosed |
| CN-101072787-A | Substituted adenines and the use thereof | ASTRAZENECA AB (SE) | 2007-11-14 | — | — | CN | disclosed |
| WO-2007113538-A1 | SUBSTITUTED ADENINES AND THE USES THEREOF | ASTRAZENECA AB (SE) | 2007-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048203-A1 | SUBSTITUTED ADENINES AND THE USES THEREOF | HPRT1, APRT, NUDT1 | BRD4 2828/4885CCNB2 2316/4885CCNE2 3471/4885 |
| US-20090118220-A1 | SUBSTITUTED ADENINES AND THE USES THEREOF | HPRT1, APRT, NUDT1 | BRD4 2829/4885CCNB2 2264/4885CCNE2 3269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.