Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3892697 | 0.72 | — | — | |
| SCHEMBL7566819 | 0.63 | TP53 (0.30) | ELANETP53 | |
| SCHEMBL21084790 | 0.60 | ELANE (0.48) | ELANEMAOBMAOAALDH1A1TP53 | |
| SCHEMBL10319810 | 0.59 | ESR1 (0.31) | — | |
| Hydrochloric Acid SCHEMBL252474 | 0.59 | — | — | |
| SCHEMBL29256181 | 0.59 | ELANE (0.56) | ELANEMAOBMAOAALDH1A1TP53 | |
| Hydrochloric Acid SCHEMBL31164305 | 0.58 | SIGMAR1 (0.39) | MAOBMAOA | |
| SCHEMBL18239154 | 0.58 | PNMT (0.33) | MAOBMAOA | |
| Hydrochloric Acid SCHEMBL10323375 | 0.56 | MAOA (0.40) | MAOBMAOAKDM4EALDH1A1TDP1 | |
| SCHEMBL27313949 | 0.55 | TP53 (0.55) | MAOBMAOAKDM4EALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1241188-B1 | COMPONENT OF CATALYST FOR OLEFIN POLYMERIZATION | JAPAN POLYCHEM CORP (JP) | 2009-01-21 | — | — | EP | disclosed |
| US-6677411-B2 | AS CATALYST SUPPORT AN ION-EXCHANGE LAYERED SILICATE HAVING A SPECIFIC PORE SIZE DISTRIBUTION CURVE | JAPAN POLYCHEM CORPORATION (JP) | 2004-01-13 | — | — | US | disclosed |
| US-20030027950-A1 | Component of catalyst for olefin polymerization | JAPAN POLYCHEM CORPORATION (JP) | 2003-02-06 | — | — | US | disclosed |
| EP-1241188-A1 | COMPONENT OF CATALYST FOR OLEFIN POLYMERIZATION | Japan Polychem Corporation (JP) | 2002-09-18 | — | — | EP | disclosed |