SCHEMBL389245

SCHEMBL389245

CCCCC(=O)N(Cc1ccc(-c2ccccc2)c(-c2nnn[nH]2)c1)[C@H](C(=O)O)C(C)C

nearest known ligand 0.62

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 12/20 0.62
LTB4R2 Q9NPC1 8/20 0.62
ABCB11 O95342 1/20 0.62
GP6 Q9HCN6 1/20 0.62
PTGDR2 Q9Y5Y4 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1322442 1.00 AGTR1 (0.62) AGTR1LTB4R2ABCB11GP6PTGDR2
SCHEMBL27898249 1.00 AGTR1 (0.62) AGTR1LTB4R2ABCB11GP6PTGDR2
SCHEMBL29846453 1.00 AGTR1 (0.62) AGTR1LTB4R2ABCB11GP6PTGDR2
Valsartan SCHEMBL2542 0.91 AGTR1 (0.72) AGTR1LTB4R2ABCB11GP6
Valsartan SCHEMBL21408288 0.91 AGTR1 (0.72) AGTR1LTB4R2ABCB11GP6
Valsartan SCHEMBL157179 0.91 AGTR1 (0.72) AGTR1LTB4R2ABCB11GP6
Valsartan SCHEMBL1560689 0.91 AGTR1 (0.72) AGTR1LTB4R2ABCB11GP6
Valsartan SCHEMBL2329 0.91 AGTR1 (0.72) AGTR1LTB4R2ABCB11GP6
Valsartan SCHEMBL29406387 0.91 AGTR1 (0.72) AGTR1LTB4R2ABCB11GP6
Valsartan SCHEMBL2328 0.91 AGTR1 (0.72) AGTR1LTB4R2ABCB11GP6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0724387-A4 TREATMENT OF CHRONIC ANTI-INFLAMMATORY DISEASES BY ANGIOTENSION II RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 1997-06-18 EP claimed
EP-0724387-A1 TREATMENT OF CHRONIC ANTI-INFLAMMATORY DISEASES BY ANGIOTENSION II RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1996-08-07 EP claimed
WO-1995006410-A1 TREATMENT OF CHRONIC INFLAMMATORY DISEASES BY ANGIOTENSION II RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1995-03-09 WO claimed
US-20220257551-A1 AMORPHOUS SOLID FORM OF COMPOUNDS CONTAINING S-N-VALERYL-N-{[2'-(1H-TETRAZOLE-5-YL)-BIPHENYL-4-YL]-METHYL}-VALINE AND (2R,4S)-5-BIPHENYL-4-YL-4-(3-CARBOXY-PROPIONYLAMINO)-2-METHYL-PENTANOIC ACID ETHYL ESTER MOIETIES AND SODIUM CATIONS NOVARTIS PHARMACEUTICALS CORPORATION 2022-08-18 US disclosed
US-20220133694-A1 PHARMACEUTICAL USE NOVARTIS PHARMACEUTICALS CORPORATION 2022-05-05 US disclosed
US-20180344679-A1 COMPOUNDS CONTAINING S-N-VALERYL-N-{[2'-(1H-TETRAZOLE-5-YL)-BIPHENYL-4-YL]-METHYL}-VALINE AND (2R,4S)-5-BIPHENYL-4-YL-4-(3-CARBOXY-PROPIONYLAMINO)-2-METHYL-PENTANOIC ACID ETHYL ESTER MOIETIES AND CATIONS NOVARTIS PHARMACEUTICALS CORPORATION 2018-12-06 US disclosed
US-8796331-B2 Methods of treatment and pharmaceutical composition NOVARTIS AG (CH) 2014-08-05 US disclosed
US-20130158086-A1 METHODS OF TREATMENT AND PHARMACEUTICAL COMPOSITION NOVARTIS AG (CH) 2013-06-20 US disclosed
US-20130158085-A1 METHODS OF TREATMENT AND PHARMACEUTICAL COMPOSITION NOVARTIS AG (CH) 2013-06-20 US disclosed
US-8404744-B2 Methods of treatment and pharmaceutical composition NOVARTIS AG (CH) 2013-03-26 US disclosed
US-20120138506-A1 METHODS OF TREATMENT AND PHARMACEUTICAL COMPOSITION NOVARTIS AG (CH) 2012-06-07 US disclosed
US-20050101652-A1 New salt hydrates NOVARTIS PHARMACEUTICALS CORPORATION 2005-05-12 US disclosed
EP-1505965-A1 USE OF VALSARTAN OT ITS METABOLITE TO INHIBIT PLATELET AGGREGATION Novartis AG (CH) 2005-02-16 EP disclosed
US-20050004194-A1 Use of organic compounds GRAVES KURT CHUM (CH) 2005-01-06 US disclosed
EP-1467728-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING VALSARTAN AND NEP INHIBITORS Novartis AG (CH) 2004-10-20 EP disclosed
WO-2004054575-A1 COMBINATIONS OF VALSARTAN WITH COX-2 INHIBITORS NOVARTIS AG (CH) 2004-07-01 WO disclosed
WO-2003094915-A1 USE OF VALSARTAN OT ITS METABOLITE TO INHIBIT PLATELET AGGREGATION NOVARTIS AG (CH) 2003-11-20 WO disclosed
US-20030144215-A1 Angiotensin antagonist valsartan and an enkephalinase inhibitor; used to treat cardiovascular disorders NOVARTIS PHARMACEUTICALS CORPORATION 2003-07-31 US disclosed
WO-2003059345-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING VALSARTAN AND NEP INHIBITORS NOVARTIS AG (CH) 2003-07-24 WO disclosed
US-5965592-A HYPOTENSIVE AGENTS NOVARTIS CORPORATION (US) 1999-10-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220133694-A1 PHARMACEUTICAL USE TNNT2, TNNI3, NPPA AGTR1 1236/4885LTB4R2 1417/4885ABCB11 14/4885
US-20030144215-A1 Angiotensin antagonist valsartan and an enkephalinase inhibitor; used to treat cardiovascular disorders MME, REN, AGTR1 AGTR1 3/4885LTB4R2 1816/4885ABCB11 1792/4885
US-20050101652-A1 New salt hydrates REN, ACE, AGT AGTR1 8/4885LTB4R2 4208/4885ABCB11 422/4885
US-20130158086-A1 METHODS OF TREATMENT AND PHARMACEUTICAL COMPOSITION REN, AGTR1, TTR AGTR1 2/4885LTB4R2 2125/4885ABCB11 713/4885
US-20050004194-A1 Use of organic compounds ACE, ACE2, AGT AGTR1 4/4885LTB4R2 869/4885ABCB11 1237/4885
US-20120138506-A1 METHODS OF TREATMENT AND PHARMACEUTICAL COMPOSITION REN, MME, ACE AGTR1 4/4885LTB4R2 1382/4885ABCB11 151/4885
US-20220257551-A1 AMORPHOUS SOLID FORM OF COMPOUNDS CONTAINING S-N-VALERYL-N-{[2'-(1H-TETRAZOLE-5-YL)-BIPHENYL-4-YL]-METHYL}-VALINE AND (2R,4S)-5-BIPHENYL-4-YL-4-(3-CARBOXY-PROPIONYLAMINO)-2-METHYL-PENTANOIC ACID ETHYL ESTER MOIETIES AND SODIUM CATIONS MME, DNPEP, AGTR1 AGTR1 3/4885LTB4R2 2298/4885ABCB11 2470/4885
US-20130158085-A1 METHODS OF TREATMENT AND PHARMACEUTICAL COMPOSITION REN, AGTR1, TTR AGTR1 2/4885LTB4R2 2125/4885ABCB11 713/4885
US-20180344679-A1 COMPOUNDS CONTAINING S-N-VALERYL-N-{[2'-(1H-TETRAZOLE-5-YL)-BIPHENYL-4-YL]-METHYL}-VALINE AND (2R,4S)-5-BIPHENYL-4-YL-4-(3-CARBOXY-PROPIONYLAMINO)-2-METHYL-PENTANOIC ACID ETHYL ESTER MOIETIES AND CATIONS REN, MME, AGTR1 AGTR1 3/4885LTB4R2 767/4885ABCB11 1196/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.