Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28479323 | 0.85 | L3MBTL1 (0.51) | L3MBTL1TRPA1MTNR1APPARDKDM4E | |
| SCHEMBL11552066 | 0.84 | ALDH1A1 (0.52) | KDM4EALDH1A1 | |
| SCHEMBL5164271 | 0.80 | KDM4E (0.47) | TRPA1MTNR1AKDM4EPPARGALDH1A1 | |
| SCHEMBL5166899 | 0.79 | TRPA1 (0.44) | TRPA1MTNR1AKDM4EALDH1A1CYP3A4 | |
| SCHEMBL3818208 | 0.78 | KDM4E (0.50) | L3MBTL1KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL2556550 | 0.78 | L3MBTL1 (0.59) | L3MBTL1KDM4EALDH1A1MAPK1MAPT | |
| SCHEMBL5166963 | 0.77 | TRPA1 (0.45) | TRPA1MTNR1AKDM4EALDH1A1CYP3A4 | |
| SCHEMBL4241452 | 0.77 | ALDH1A1 (0.61) | L3MBTL1TRPA1MTNR1AKDM4EPPARG | |
| SCHEMBL637156 | 0.77 | KDM4E (0.56) | L3MBTL1KDM4EALDH1A1CASP1NPSR1 | |
| SCHEMBL3910119 | 0.75 | TRPA1 (0.44) | L3MBTL1TRPA1MTNR1AKDM4EPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1768945-B1 | SUBSTITUTED HYDROXYACETOPHENON DERIVATIVES | RIEMSER ARZNEIMITTEL AG (DE) | 2009-03-18 | — | — | EP | claimed |
| EP-1768945-A1 | SUBSTITUTED HYDROXYACETOPHENON DERIVATIVES | Riemser Arzneimittel AG (DE) | 2007-04-04 | — | — | EP | claimed |
| WO-2006003010-A1 | SUBSTITUTED HYDROXYACETOPHENON DERIVATIVES | RIEMSER ARZNEIMITTEL AG (DE) | 2006-01-12 | — | — | WO | claimed |
| EP-1768945-A1 | SUBSTITUTED HYDROXYACETOPHENON DERIVATIVES | Riemser Arzneimittel AG (DE) | 2007-04-04 | — | — | EP | disclosed |
| WO-2006003010-A1 | SUBSTITUTED HYDROXYACETOPHENON DERIVATIVES | RIEMSER ARZNEIMITTEL AG (DE) | 2006-01-12 | — | — | WO | disclosed |