Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.52 |
| ▸ | SDHB | P21912 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | STAT3 | P40763 | 2/20 | 0.47 |
| ▸ | STAT1 | P42224 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3568019 | 0.87 | SDHB (0.54) | PTGS2SDHBLMNASTAT3STAT1 | |
| SCHEMBL3562889 | 0.81 | SDHB (0.48) | PTGS2SDHBLMNASTAT3STAT1 | |
| SCHEMBL3898550 | 0.79 | ADORA2A (0.72) | LMNAMEN1HPGDKMT2AHSD17B10 | |
| SCHEMBL28071862 | 0.79 | ADORA2A (0.59) | LMNAMEN1HPGDKMT2AHSD17B10 | |
| SCHEMBL4659067 | 0.78 | SDHB (0.47) | PTGS2SDHBLMNASTAT3STAT1 | |
| SCHEMBL3568722 | 0.77 | PTGES2 (0.48) | SDHBLMNASTAT3STAT1RAB9A | |
| SCHEMBL3557424 | 0.77 | LRRK2 (0.47) | PTGS2PTGS1SYK | |
| SCHEMBL3910159 | 0.76 | ADORA2A (0.53) | RAB9AMEN1HPGDKMT2AHSD17B10 | |
| SCHEMBL3560314 | 0.75 | NR1H2 (0.50) | PTGS2SDHBNR1H2NR1H3SYK | |
| SCHEMBL3898780 | 0.75 | ADORA2A (0.51) | SDHBLMNAMEN1TP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7524874-B2 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. (US) | 2009-04-28 | — | — | US | disclosed |
| US-20050267163-A1 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. | 2005-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050267163-A1 | Vanilloid receptor ligands and their use in treatments | TRPV1, TRPV2, TRPV3 | PTGS2 176/4885SDHB 3696/4885LMNA 3886/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.