Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 2/20 | 1.00 |
| ▸ | PTGS2 | P35354 | 2/20 | 1.00 |
| ▸ | ALOX5AP | P20292 | 1/20 | 1.00 |
| ▸ | EPOR | P19235 | 8/20 | 0.68 |
| ▸ | KDM5A | P29375 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | TLR4 | O00206 | 1/20 | 0.47 |
| ▸ | TLR2 | O60603 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3903195 | 1.00 | ALOX5 (1.00) | ALOX5PTGS1PTGS2ALOX5APEPOR | |
| SCHEMBL29808733 | 1.00 | ALOX5 (1.00) | ALOX5PTGS1PTGS2ALOX5APEPOR | |
| SCHEMBL9707330 | 0.82 | ALOX5 (0.69) | ALOX5PTGS1PTGS2ALOX5APEPOR | |
| SCHEMBL26357305 | 0.80 | ALOX5 (0.67) | ALOX5PTGS1PTGS2ALOX5APEPOR | |
| SCHEMBL9707266 | 0.76 | ALOX5 (0.61) | ALOX5PTGS1PTGS2ALOX5APEPOR | |
| SCHEMBL9781059 | 0.76 | ALOX5 (0.70) | ALOX5PTGS1PTGS2ALOX5APEPOR | |
| SCHEMBL9781055 | 0.76 | ALOX5 (0.70) | ALOX5PTGS1PTGS2ALOX5APEPOR | |
| SCHEMBL6008832 | 0.75 | ALOX5 (0.66) | ALOX5PTGS1PTGS2ALOX5APEPOR | |
| SCHEMBL6008836 | 0.75 | ALOX5 (0.66) | ALOX5PTGS1PTGS2ALOX5APEPOR | |
| SCHEMBL6008840 | 0.75 | ALOX5 (0.66) | ALOX5PTGS1PTGS2ALOX5APEPOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572185-A4 | LIPOXYGENASE INHIBITORS AS HYPOLIPIDEMIC AND ANTI-HYPERTENSIVE AGENTS | INSMED INC (US) | 2009-02-25 | — | — | EP | claimed |
| EP-1572185-A1 | LIPOXYGENASE INHIBITORS AS HYPOLIPIDEMIC AND ANTI-HYPERTENSIVE AGENTS | Insmed Incorporated (US) | 2005-09-14 | — | — | EP | claimed |
| US-20040198800-A1 | Lipoxygenase inhibitors as hypolipidemic and anti-hypertensive agents | INSMED INCORPORATED | 2004-10-07 | — | — | US | claimed |
| WO-2004058240-A1 | LIPOXYGENASE INHIBITORS AS HYPOLIPIDEMIC AND ANTI-HYPERTENSIVE AGENTS | INSMED INCORPORATED (US) | 2004-07-15 | — | — | WO | claimed |
| EP-0196184-B1 | ARYL DERIVATIVES | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-09-16 | — | — | EP | claimed |
| US-4977188-A | Hydroamic acid derivatives | BURROUGHS WELLCOME CO. (US) | 1990-12-11 | — | — | US | claimed |
| WO-1990001929-A1 | NEW MEDICAL USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-03-08 | — | — | WO | claimed |
| US-4738986-A | CYCLOOXYGENASE, LIDOXYGENASE INHIBITORS | BURROUGHS WELLCOME CO. (US) | 1988-04-19 | — | — | US | claimed |
| EP-0196184-A2 | Aryl derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-10-01 | — | — | EP | claimed |
| JP-6183960-A | — | — | None | — | — | JP | disclosed |
| EP-3341366-A1 | TOCOTRIENOL DERIVATIVES, PHARMACEUTICAL COMPOSITION AND METHOD OF USE IN 5-LIPOXYGENASE RELATED DISEASES | Université d'Angers (FR) | 2018-07-04 | — | — | EP | disclosed |
| WO-2017032881-A1 | TOCOTRIENOL DERIVATIVES, PHARMACEUTICAL COMPOSITION AND METHOD OF USE IN 5-LIPOXYGENASE RELATED DISEASES | Université d'Angers (FR) | 2017-03-02 | — | — | WO | disclosed |
| WO-2014176460-A1 | METHODS OF TREATING BEHAVIORIAL AND/OR MENTAL DISORDERS | CHAU DAVID T (US) | 2014-10-30 | — | — | WO | disclosed |
| US-8486922-B2 | Composition | CHEN CHIEN-HUNG (TW) | 2013-07-16 | — | — | US | disclosed |
| US-4977188-A | Hydroamic acid derivatives | BURROUGHS WELLCOME CO. (US) | 1990-12-11 | — | — | US | disclosed |
| WO-1990001929-A1 | NEW MEDICAL USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-03-08 | — | — | WO | disclosed |
| EP-0299761-A1 | Anti-inflammatory aryl derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1989-01-18 | — | — | EP | disclosed |
| US-4738986-A | CYCLOOXYGENASE, LIDOXYGENASE INHIBITORS | BURROUGHS WELLCOME CO. (US) | 1988-04-19 | — | — | US | disclosed |
| US-4738986-A | CYCLOOXYGENASE, LIDOXYGENASE INHIBITORS | BURROUGHS WELLCOME CO. (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0196184-A2 | Aryl derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-10-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040198800-A1 | Lipoxygenase inhibitors as hypolipidemic and anti-hypertensive agents | ALOX5, ALOX15, ALOX15B | ALOX5 1/4885PTGS1 14/4885PTGS2 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.