Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 11/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 2/20 | 0.48 |
| ▸ | BCR | P11274 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3901114 | 0.86 | HDAC3 (0.55) | HDAC3HDAC1HDAC2NPC1ALDH1A1 | |
| SCHEMBL764280 | 0.85 | ABL1 (0.53) | HDAC3HDAC1HDAC2NPC1ALDH1A1 | |
| SCHEMBL764282 | 0.83 | HDAC3 (0.52) | HDAC3HDAC1HDAC2NPC1ALDH1A1 | |
| SCHEMBL764268 | 0.83 | ABL1 (0.54) | HDAC3HDAC1HDAC2NPC1ALDH1A1 | |
| SCHEMBL3896505 | 0.80 | HPGD (0.58) | NPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL3898560 | 0.78 | KCNH2 (0.49) | HDAC3HDAC1HDAC2NPC1ALDH1A1 | |
| SCHEMBL21857924 | 0.78 | KCNH2 (0.62) | HDAC3HDAC1HDAC2KCNH2 | |
| SCHEMBL13833395 | 0.77 | HDAC1 (1.00) | HDAC3HDAC1HDAC2 | |
| SCHEMBL764236 | 0.76 | ABL1 (0.76) | HDAC3HDAC1HDAC2NPC1ALDH1A1 | |
| SCHEMBL13833557 | 0.75 | HDAC1 (1.00) | HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241759-B2 | Benzo[1,2,5]thiadiazole compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-10 | — | — | US | claimed |
| US-7550492-B2 | Benzo[1,2,5]thiadiazole compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-06-23 | — | — | US | disclosed |
| US-20070276016-A1 | BENZO[1,2,5]THIADIAZOLE COMPOUNDS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-11-29 | — | — | US | disclosed |
| US-7241759-B2 | Benzo[1,2,5]thiadiazole compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-10 | — | — | US | disclosed |
| US-20040224983-A1 | Benzo[1,2,5]thiadiazole compounds | JANSSEN PHARMACEUTICA, N.V. (BE) | 2004-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070276016-A1 | BENZO[1,2,5]THIADIAZOLE COMPOUNDS | CCKBR, CCKAR, GIPR | HDAC3 1351/4885HDAC1 1315/4885HDAC2 576/4885 |
| US-20040224983-A1 | Benzo[1,2,5]thiadiazole compounds | CCKBR, CCKAR, BRSK2 | HDAC3 1420/4885HDAC1 1173/4885HDAC2 418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.