Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 3/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 4/20 | 0.49 |
| ▸ | BCR | P11274 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL764268 | 0.84 | ABL1 (0.54) | HDAC3HDAC1HDAC2HPGDNPC1 | |
| SCHEMBL3901121 | 0.83 | HDAC3 (0.62) | HDAC3HDAC1HDAC2HPGDNPC1 | |
| SCHEMBL764280 | 0.83 | ABL1 (0.53) | HDAC3HDAC1HDAC2HPGDNPC1 | |
| SCHEMBL3901114 | 0.82 | HDAC3 (0.55) | HDAC3HDAC1HDAC2HPGDNPC1 | |
| SCHEMBL10331354 | 0.79 | YEATS4 (0.54) | HDAC3HDAC1HDAC2HPGDNPC1 | |
| SCHEMBL764236 | 0.77 | ABL1 (0.76) | HDAC3HDAC1HDAC2HPGDNPC1 | |
| SCHEMBL10331952 | 0.75 | HPGD (0.53) | HPGDNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL10198116 | 0.75 | ABL1 (0.76) | HDAC3HDAC1HDAC2HPGDNPC1 | |
| SCHEMBL24508969 | 0.74 | P2RX7 (0.60) | HPGDNPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL29944105 | 0.72 | MEN1 (0.62) | HPGDNPC1TP53RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078015-B1 | MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1 AND/OR NF-KAPPAB ACTIVITY AND USE THEREOF | BRISTOL MYERS SQUIBB CO (US) | 2012-03-21 | — | — | EP | disclosed |