Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 2/20 | 0.43 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 3/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3906498 | 1.00 | MMP8 (0.43) | MMP8CYP4F2CYP4A11ALDH1A1POLB | |
| SCHEMBL3903236 | 1.00 | MMP8 (0.43) | MMP8CYP4F2CYP4A11ALDH1A1POLB | |
| SCHEMBL31423716 | 1.00 | MMP8 (0.43) | MMP8CYP4F2CYP4A11ALDH1A1POLB | |
| SCHEMBL4427462 | 0.88 | MMP8 (0.47) | MMP8CYP4F2CYP4A11ALDH1A1POLB | |
| SCHEMBL8160331 | 0.82 | ALDH1A1 (0.44) | MMP8CYP4F2CYP4A11ALDH1A1PKM | |
| SCHEMBL15109846 | 0.80 | MMP8 (0.42) | MMP8CYP4F2CYP4A11ALDH1A1POLB | |
| SCHEMBL14403317 | 0.80 | ALOX15 (0.46) | MMP8CYP4F2CYP4A11ALDH1A1POLB | |
| SCHEMBL14403192 | 0.80 | ALOX15 (0.46) | MMP8CYP4F2CYP4A11ALDH1A1POLB | |
| Trifluoroacetic Acid SCHEMBL10523981 | 0.79 | ALDH1A1 (0.42) | CYP4F2CYP4A11ALDH1A1POLBNPSR1 | |
| SCHEMBL3372776 | 0.79 | ALDH1A1 (0.42) | MMP8CYP4F2CYP4A11ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2018368-B1 | MALONAMIDE DERIVATIVES AS GAMMA SECRETASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2012-12-05 | — | — | EP | disclosed |
| EP-2018368-A1 | MALONAMIDE DERIVATIVES AS GAMMA SECRETASE INHIBITORS | F. Hoffmann-Roche AG (CH) | 2009-01-28 | — | — | EP | disclosed |
| US-7425551-B2 | Malonamide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-09-16 | — | — | US | disclosed |
| WO-2007110335-A1 | MALONAMIDE DERIVATIVES AS GAMMA SECRETASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-04 | — | — | WO | disclosed |
| US-20070225273-A1 | Malonamide derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2007-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225273-A1 | Malonamide derivatives | ACE, APP, NAAA | MMP8 4825/4885CYP4F2 1024/4885CYP4A11 440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.