Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3905806 | 0.87 | P2RX7 (0.42) | P2RX7SMN1; SMN2RAB9AALDH1A1MAPT | |
| SCHEMBL3902047 | 0.86 | MTNR1A (0.39) | MTNR1AMTNR1BALDH1A1MAPT | |
| SCHEMBL3907851 | 0.84 | HIF1A (0.42) | MTNR1AMTNR1BALDH1A1MAPT | |
| SCHEMBL3903152 | 0.82 | OPRM1 (0.40) | MTNR1ASMN1; SMN2MAPT | |
| SCHEMBL3904588 | 0.82 | P2RX7 (0.42) | P2RX7MTNR1AMTNR1BSMN1; SMN2NPC1 | |
| SCHEMBL3905440 | 0.80 | HIF1A (0.40) | MTNR1ASMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL3910650 | 0.78 | OPRM1 (0.43) | MTNR1ASMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL3915781 | 0.77 | CNR1 (0.39) | MTNR1AMTNR1BNPC1RAB9AMEN1 | |
| SCHEMBL3907346 | 0.75 | TAAR1 (0.53) | SMN1; SMN2MAPT | |
| SCHEMBL3907196 | 0.75 | S1PR2 (0.39) | MTNR1AMTNR1BSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2018364-A1 | THERAPEUTIC FLUOROETHYL UREAS | Allergan, Inc. (US) | 2009-01-28 | — | — | EP | claimed |
| WO-2007137029-A1 | THERAPEUTIC FLUOROETHYL UREAS | ALLERGAN, INC. (US) | 2007-11-29 | — | — | WO | claimed |
| EP-2018364-A1 | THERAPEUTIC FLUOROETHYL UREAS | Allergan, Inc. (US) | 2009-01-28 | — | — | EP | disclosed |
| WO-2007137029-A1 | THERAPEUTIC FLUOROETHYL UREAS | ALLERGAN, INC. (US) | 2007-11-29 | — | — | WO | disclosed |