Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 11/20 | 0.40 |
| ▸ | THRB | P10828 | 11/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3141253 | 0.90 | ALDH1A1 (0.40) | THRATHRBLMNAMAPTMEN1 | |
| SCHEMBL5858364 | 0.83 | THRB (0.52) | THRATHRBLMNAPPARG | |
| SCHEMBL3913459 | 0.81 | THRA (0.54) | THRATHRBLMNAPOLB | |
| SCHEMBL5859445 | 0.79 | LMNA (0.42) | THRATHRBLMNAMAPTTDP1 | |
| SCHEMBL27874611 | 0.78 | ALDH1A1 (0.42) | THRATHRBLMNAMAPTMEN1 | |
| SCHEMBL3909957 | 0.77 | KMT2A (0.46) | THRATHRBLMNAMAPTMEN1 | |
| SCHEMBL3910714 | 0.77 | KMT2A (0.46) | THRATHRBLMNAMAPTMEN1 | |
| SCHEMBL7114898 | 0.75 | MAPT (0.43) | LMNAMAPTTDP1MEN1POLB | |
| SCHEMBL3911699 | 0.75 | KMT2A (0.40) | THRATHRBLMNAMAPTMEN1 | |
| SCHEMBL3910551 | 0.74 | THRA (0.41) | THRATHRBPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024336-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS | KARO BIO AB (SE) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007128492-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS | KARO BIO AB (SE) | 2007-11-15 | — | — | WO | disclosed |