SCHEMBL8885016

SCHEMBL8885016

NS(=O)(=O)c1ncccc1I

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 10/20 0.43
CA2 P00918 10/20 0.43
CA9 Q16790 8/20 0.43
MAPK1 P28482 1/20 0.43
FTO Q9C0B1 1/20 0.40
KMT2A Q03164 2/20 0.39
CA12 O43570 7/20 0.38
LMNA P02545 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2C9 P11712 1/20 0.36
HIF1A Q16665 1/20 0.36
PHLPP2 Q6ZVD8 1/20 0.36
HSD17B10 Q99714 1/20 0.36
KDM4E B2RXH2 1/20 0.35
ALOX12 P18054 1/20 0.35
TDP2 O95551 1/20 0.34
NSD2 O96028 1/20 0.34
ABL1 P00519 1/20 0.34
PLCG1 P19174 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30665364 0.79 TRPV4 (0.42) CA1CA2MAPK1KMT2ALMNA
SCHEMBL23665012 0.79 KMT2A (0.39) KMT2ATDP2NSD2ABL1PLCG1
SCHEMBL14120534 0.77 CA2 (0.45) CA1CA2CA9MAPK1FTO
SCHEMBL10480797 0.77 CA1 (0.58) CA1CA2CA9MAPK1FTO
SCHEMBL8537341 0.77 FTO (0.49) CA1CA2CA9MAPK1FTO
SCHEMBL390770 0.77 KMT2A (0.56) CA1CA2CA9MAPK1FTO
SCHEMBL6098339 0.75 LMNA (0.50) CA1CA2CA9MAPK1FTO
SCHEMBL9256203 0.75 CA1 (0.43) CA1CA2CA9MAPK1FTO
SCHEMBL3636398 0.75 NOS3 (0.48) CA1CA2CA9MAPK1FTO
SCHEMBL8536255 0.75 CA1 (0.43) CA1CA2CA9MAPK1FTO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1044765-C Pyridylsulfonylurea herbicides and agent for regulating plant growth HOECHST AG (DE) 1999-08-25 CN disclosed
US-5635451-A Pyridylsulfonylureas as herbicides and plant growth regulators, processes for their preparation and their use HOECHST SCHERING AGREVO GMBH (DE) 1997-06-03 US disclosed
US-5576440-A 2-pyridylsulfonamides HOECHST AKTIENGESELLSCHAFT (DE) 1996-11-19 US disclosed
EP-0510032-B1 USE OF PYRIDYL SULPHONYL UREAS AS HERBICIDES AND PLANT GROWTH REGULATORS, PROCESS FOR PRODUCING THEM AND THEIR USE HOECHST SCHERING AGREVO GMBH (DE) 1996-11-13 EP disclosed
US-5529976-A PRE-AND POST-EMERGENCE HERBICIDES; TOLERATED BY CROP PLANTS HOECHST AKTIENGESELLSCHAFT (DE) 1996-06-25 US disclosed
US-5494886-A PRE- AND POST-EMERGENCE HOECHST AKTIENGESELLSCHAFT (DE) 1996-02-27 US disclosed
EP-0510032-A1 USE OF PYRIDYL SULPHONYL UREAS AS HERBICIDES AND PLANT GROWTH REGULATORS, PROCESS FOR PRODUCING THEM AND THEIR USE. HOECHST AG (DE) 1992-10-28 EP disclosed
WO-1991010660-A1 USE OF PYRIDYL SULPHONYL UREAS AS HERBICIDES AND PLANT GROWTH REGULATORS, PROCESS FOR PRODUCING THEM AND THEIR USE HOECHST AKTIENGESELLSCHAFT (DE) 1991-07-25 WO disclosed
CN-1053236-A Pyridine sulfonylurea weedicide and plant-growth regulator, their preparation method and application HOECHST AG (DE) 1991-07-24 CN disclosed