Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F7 | P08709 | 1/20 | 0.42 |
| ▸ | F3 | P13726 | 1/20 | 0.42 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.42 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.42 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.42 |
| ▸ | P2RY2 | P41231 | 6/20 | 0.42 |
| ▸ | P2RY6 | Q15077 | 6/20 | 0.42 |
| ▸ | P2RY4 | P51582 | 5/20 | 0.42 |
| ▸ | P2RY14 | Q15391 | 7/20 | 0.41 |
| ▸ | B4GALT1 | P15291 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Niacinamide SCHEMBL3915026 | 0.98 | F7 (0.44) | F7F3SARM1SIRT2SIRT6 | |
| Niacinamide SCHEMBL30498617 | 0.90 | F7 (0.48) | F7F3SARM1SIRT2SIRT6 | |
| Niacinamide SCHEMBL28184048 | 0.90 | F7 (0.48) | F7F3SARM1SIRT2SIRT6 | |
| Niacinamide SCHEMBL20398298 | 0.83 | F7 (0.55) | F7F3SARM1SIRT2SIRT6 | |
| Niacinamide SCHEMBL28671370 | 0.82 | F7 (0.46) | F7F3SARM1SIRT2SIRT6 | |
| SCHEMBL28254206 | 0.82 | MAOB (0.39) | P2RY2P2RY6P2RY4P2RY14B4GALT1 | |
| Niacinamide SCHEMBL28136690 | 0.80 | F7 (0.51) | F7F3SARM1SIRT2SIRT6 | |
| Ribose (Furanose) SCHEMBL17315030 | 0.80 | F7 (0.54) | F7F3SARM1SIRT2SIRT6 | |
| Niacinamide SCHEMBL17315028 | 0.79 | F7 (0.50) | F7F3SARM1SIRT2SIRT6 | |
| Niacinamide SCHEMBL21571784 | 0.79 | F7 (0.50) | F7F3SARM1SIRT2SIRT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8383086-B2 | Nicotinamide riboside kinase compositions and methods for using the same | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2013-02-26 | — | — | US | disclosed |
| US-20120251463-A1 | Nicotinamide Riboside Kinase Compositions and Methods for Using the Same | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2012-10-04 | — | — | US | disclosed |
| US-8197807-B2 | Nucleotide sequences coding muscle specific integrin binding protein for use as tool in targeting cancer cells for destruction | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2012-06-12 | — | — | US | disclosed |
| EP-1877068-A4 | NICOTINAMIDE RIBOSIDE KINASE COMPOSITIONS AND METHODS FOR USING THE SAME | DARTMOUTH COLLEGE (US) | 2009-01-21 | — | — | EP | disclosed |
| US-20080206221-A1 | Nicotinamide Riboside Kinase Compositions and Methods for Using the Same | WESTERN ALLIANCE BANK | 2008-08-28 | — | — | US | disclosed |
| EP-1877068-A2 | NICOTINAMIDE RIBOSIDE KINASE COMPOSITIONS AND METHODS FOR USING THE SAME | Trustees of Dartmouth College (US) | 2008-01-16 | — | — | EP | disclosed |
| EP-1723227-A4 | NICOTINAMIDE RIBOSIDE KINASE COMPOSITIONS AND METHODS FOR USING THE SAME | DARTMOUTH COLLEGE (US) | 2007-09-19 | — | — | EP | disclosed |
| US-20070027095-A1 | Nicotinamide riboside kinase compositions and methods for using the same | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2007-02-01 | — | — | US | disclosed |
| EP-1723227-A2 | NICOTINAMIDE RIBOSIDE KINASE COMPOSITIONS AND METHODS FOR USING THE SAME | Trustees of Dartmouth College (US) | 2006-11-22 | — | — | EP | disclosed |
| WO-2006116322-A2 | NICOTINAMIDE RIBOSIDE KINASE COMPOSITIONS AND METHODS FOR USING THE SAME | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2006-11-02 | — | — | WO | disclosed |
| US-20050227327-A1 | Nicotinamide riboside kinase compositions and methods for using the same | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-10-13 | — | — | US | disclosed |
| WO-2005077091-A2 | NICOTINAMIDE RIBOSIDE KINASE COMPOSITIONS AND METHODS FOR USING THE SAME | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2005-08-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050227327-A1 | Nicotinamide riboside kinase compositions and methods for using the same | NADK, NAMPT, NME2 | F7 4533/4885F3 2314/4885SARM1 66/4885 |
| US-20080206221-A1 | Nicotinamide Riboside Kinase Compositions and Methods for Using the Same | NADK, NAMPT, NME2 | F7 4533/4885F3 2314/4885SARM1 66/4885 |
| US-20070027095-A1 | Nicotinamide riboside kinase compositions and methods for using the same | NADK, NAMPT, NME2 | F7 4533/4885F3 2314/4885SARM1 66/4885 |
| US-20120251463-A1 | Nicotinamide Riboside Kinase Compositions and Methods for Using the Same | NADK, NAMPT, NME2 | F7 4533/4885F3 2314/4885SARM1 66/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.