Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4181628 | 0.81 | — | — | |
| SCHEMBL883906 | 0.78 | HRH3 (0.38) | — | |
| SCHEMBL4084448 | 0.75 | CYP3A4 (0.33) | ACLY | |
| SCHEMBL4084440 | 0.75 | CYP3A4 (0.33) | ACLY | |
| SCHEMBL884195 | 0.75 | SPR (0.35) | — | |
| SCHEMBL4184706 | 0.74 | — | — | |
| SCHEMBL5504186 | 0.74 | F10 (0.35) | — | |
| SCHEMBL2065090 | 0.70 | ESR1 (0.32) | — | |
| SCHEMBL2065091 | 0.70 | ESR1 (0.32) | — | |
| SCHEMBL4179287 | 0.70 | KDM4E (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2016071-A1 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2009-01-21 | — | — | EP | disclosed |
| WO-2007127765-A1 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-11-08 | — | — | WO | disclosed |