Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 7/20 | 0.35 |
| ▸ | NAMPT | P43490 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL883906 | 0.90 | HRH3 (0.38) | HTR2BHRH3 | |
| SCHEMBL4183670 | 0.87 | SPR (0.34) | SPRNAMPTHTR2BHRH3 | |
| SCHEMBL4189000 | 0.81 | HRH3 (0.34) | SPRNAMPTKMT2AHRH3 | |
| SCHEMBL4188991 | 0.80 | ALDH1A1 (0.36) | SPRNAMPTHRH3 | |
| SCHEMBL2065163 | 0.80 | L3MBTL1 (0.39) | SPRNAMPTHTR2BKMT2A | |
| SCHEMBL2023490 | 0.80 | L3MBTL1 (0.39) | SPRNAMPTHTR2BKMT2A | |
| SCHEMBL1093931 | 0.76 | NAMPT (0.46) | SPRNAMPTHTR2B | |
| SCHEMBL1093625 | 0.76 | HTR2B (0.37) | SPRNAMPTHTR2BHRH3 | |
| SCHEMBL1092071 | 0.76 | HTR2B (0.37) | SPRNAMPTHTR2BHRH3 | |
| SCHEMBL1092073 | 0.76 | HTR2B (0.37) | SPRNAMPTHTR2BHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2016071-A1 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2009-01-21 | — | — | EP | claimed |
| WO-2007127765-A1 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-11-08 | — | — | WO | claimed |
| EP-2016071-A1 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2009-01-21 | — | — | EP | disclosed |
| WO-2007127765-A1 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-11-08 | — | — | WO | disclosed |