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SCHEMBL390924

SCHEMBL390924

CC(=O)NN(C(=O)OC(C)(C)C)C(C)c1ccc(Cl)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MT-CO2 P00403 1/20 0.40
▸ UTS2R Q9UKP6 3/20 0.38
▸ P2RY2 P41231 1/20 0.37
▸ BRD4 O60885 1/20 0.36
▸ FFAR2 O15552 2/20 0.36
▸ L3MBTL1 Q9Y468 1/20 0.36
▸ CHRNB2 P17787 1/20 0.36
▸ CHRNB4 P30926 1/20 0.36
▸ CHRNA3 P32297 1/20 0.36
▸ CHRNA4 P43681 1/20 0.36
▸ TRPA1 O75762 1/20 0.35
▸ APP P05067 1/20 0.35
▸ ALDH1A1 P00352 1/20 0.35
▸ CYP3A4 P08684 2/20 0.35
▸ CYP1A2 P05177 1/20 0.35
▸ CYP2D6 P10635 1/20 0.35
▸ CYP2C9 P11712 1/20 0.35
▸ NFKB1 P19838 1/20 0.35
▸ CYP2C19 P33261 1/20 0.35
▸ GAA P10253 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL392218 0.80 GRIN2D (0.41) MT-CO2UTS2RBRD4FFAR2L3MBTL1
SCHEMBL22327650 0.80 MT-CO2 (0.42) MT-CO2UTS2RBRD4FFAR2L3MBTL1
SCHEMBL20544517 0.80 BRD4 (0.42) UTS2RBRD4FFAR2L3MBTL1ALDH1A1
SCHEMBL17497820 0.71 MTOR (0.44) ALDH1A1GAA
SCHEMBL12047805 0.69 CHRNB2 (0.43) MT-CO2UTS2RFFAR2L3MBTL1CHRNB2
SCHEMBL15137133 0.69 CHRNB2 (0.43) MT-CO2UTS2RFFAR2L3MBTL1CHRNB2
SCHEMBL24909149 0.69 MT-CO2 (0.38) MT-CO2BRD4FFAR2APPCYP3A4
SCHEMBL7479568 0.69 MT-CO2 (0.46) MT-CO2L3MBTL1CHRNB2CHRNB4CHRNA3
SCHEMBL7479440 0.69 MT-CO2 (0.46) MT-CO2L3MBTL1CHRNB2CHRNB4CHRNA3
SCHEMBL1007329 0.68 MT-CO2 (0.51) MT-CO2CHRNB2CHRNB4CHRNA3CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12252495-B2 Protein kinase B inhibitors ASTRAZENECA AB (SE) 2025-03-18 — — US disclosed
US-20240109902-A1 PROTEIN KINASE B INHIBITORS ASTRAZENECA AB (SE) 2024-04-04 — — US disclosed
US-11760760-B2 Protein kinase B inhibitors ASTRAZENECA AB (SE) 2023-09-19 — — US disclosed
US-20220220116-A1 PROTEIN KINASE B INHIBITORS ASTRAZENECA AB (SE) 2022-07-14 — — US disclosed
US-11236095-B2 Protein kinase B inhibitors ASTRAZENECA AB (SE) 2022-02-01 — — US disclosed
US-20200239483-A1 PROTEIN KINASE B INHIBITORS ASTRAZENECA AB (SE) 2020-07-30 — — US disclosed
US-10654855-B2 Protein kinase B inhibitors ASTRAZENECA AB (SE) 2020-05-19 — — US disclosed
US-20180312516-A1 Protein Kinase B Inhibitors ASTRAZENECA AB (SE) 2018-11-01 — — US disclosed
US-10059714-B2 Protein kinase B inhibitors ASTRAZENECA AB (SE) 2018-08-28 — — US disclosed
US-20170057969-A1 Novel Protein Kinase B Inhibitors - 060 ASTRAZENECA AB (SE) 2017-03-02 — — US disclosed
US-9492453-B2 Protein kinase B inhibitors ASTRAZENECA AB (SE) 2016-11-15 — — US disclosed
US-20150182531-A1 Novel Protein Kinase B Inhibitors - 060 ASTRAZENECA AB (SE) 2015-07-02 — — US disclosed
US-20120190679-A1 Novel Protein Kinase B Inhibitors - 060 ASTRAZENECA AB (SE) 2012-07-26 — — US disclosed
US-8101623-B2 Substituted pyrrolo[2,3-d]pyrimidine as a protein kinase B inhibitor ASTRAZENECA AB (SE) 2012-01-24 — — US disclosed
US-20090163524-A1 Novel Protein Kinase B Inhibitors - 060 ASTRAZENECA AB (SE) 2009-06-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12252495-B2 Protein kinase B inhibitors PRKAR2B, PRKCB, AKT1 MT-CO2 4435/4885UTS2R 3101/4885P2RY2 1136/4885
US-20220220116-A1 PROTEIN KINASE B INHIBITORS PRKAR2B, PRKCB, AKT1 MT-CO2 4435/4885UTS2R 3101/4885P2RY2 1136/4885
US-20180312516-A1 Protein Kinase B Inhibitors PRKAR2B, PRKCB, AKT1 MT-CO2 4435/4885UTS2R 3101/4885P2RY2 1136/4885
US-10654855-B2 Protein kinase B inhibitors PRKAR2B, PRKCB, AKT1 MT-CO2 4435/4885UTS2R 3101/4885P2RY2 1136/4885
US-20240109902-A1 PROTEIN KINASE B INHIBITORS PRKAR2B, PRKCB, AKT1 MT-CO2 4435/4885UTS2R 3101/4885P2RY2 1136/4885
US-10059714-B2 Protein kinase B inhibitors PRKAR2B, PRKCB, AKT1 MT-CO2 4435/4885UTS2R 3101/4885P2RY2 1136/4885
US-20090163524-A1 Novel Protein Kinase B Inhibitors - 060 PRKAR2B, PRKCB, MAP3K20 MT-CO2 4734/4885UTS2R 2892/4885P2RY2 1335/4885
US-20170057969-A1 Novel Protein Kinase B Inhibitors - 060 PRKAR2B, PRKCB, MAP3K20 MT-CO2 4734/4885UTS2R 2892/4885P2RY2 1335/4885
US-20200239483-A1 PROTEIN KINASE B INHIBITORS PRKAR2B, PRKCB, AKT1 MT-CO2 4435/4885UTS2R 3101/4885P2RY2 1136/4885
US-20120190679-A1 Novel Protein Kinase B Inhibitors - 060 PRKAR2B, PRKCB, MAP3K20 MT-CO2 4734/4885UTS2R 2892/4885P2RY2 1335/4885
US-11236095-B2 Protein kinase B inhibitors PRKAR2B, PRKCB, AKT1 MT-CO2 4435/4885UTS2R 3101/4885P2RY2 1136/4885
US-20150182531-A1 Novel Protein Kinase B Inhibitors - 060 PRKAR2B, PRKCB, MAP3K20 MT-CO2 4734/4885UTS2R 2892/4885P2RY2 1335/4885
US-11760760-B2 Protein kinase B inhibitors PRKAR2B, PRKCB, AKT1 MT-CO2 4435/4885UTS2R 3101/4885P2RY2 1136/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.