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SCHEMBL392218

SCHEMBL392218

CC(c1ccc(Cl)cc1)N(N)C(=O)OC(C)(C)C

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GRIN2D O15399 1/20 0.41
▸ GRIN3B O60391 1/20 0.41
▸ GRIN1 Q05586 1/20 0.41
▸ GRIN2A Q12879 1/20 0.41
▸ GRIN2B Q13224 1/20 0.41
▸ GRIN2C Q14957 1/20 0.41
▸ GRIN3A Q8TCU5 1/20 0.41
▸ CYP3A4 P08684 2/20 0.40
▸ CYP1A2 P05177 1/20 0.40
▸ CYP2D6 P10635 1/20 0.40
▸ CYP2C9 P11712 1/20 0.40
▸ NFKB1 P19838 1/20 0.40
▸ CYP2C19 P33261 1/20 0.40
▸ MT-CO2 P00403 1/20 0.40
▸ LMNA P02545 1/20 0.40
▸ PMP22 Q01453 1/20 0.40
▸ NLRP3 Q96P20 1/20 0.40
▸ MEN1 O00255 1/20 0.39
▸ KMT2A Q03164 1/20 0.39
▸ ADRB2 P07550 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18176133 0.86 ESR1 (0.37) CYP3A4LMNA
SCHEMBL22327650 0.84 MT-CO2 (0.42) CYP3A4CYP1A2CYP2D6CYP2C9NFKB1
SCHEMBL118082 0.84 ALOX5 (0.47) CYP1A2CYP2D6LMNAAOC3
SCHEMBL6613322 0.84 ALOX5 (0.47) CYP1A2CYP2D6LMNAAOC3
SCHEMBL30209351 0.84 CES2 (0.40) APPUTS2R
SCHEMBL6385501 0.81 MAPT (0.41) CYP3A4CYP2C9CYP2C19
SCHEMBL20544798 0.80 ADRB2 (0.45) CYP3A4CYP1A2CYP2D6CYP2C9NFKB1
SCHEMBL390924 0.80 MT-CO2 (0.40) CYP3A4CYP1A2CYP2D6CYP2C9NFKB1
SCHEMBL2644695 0.78 LMNA (0.47) CYP3A4CYP1A2LMNAMEN1KMT2A
SCHEMBL551649 0.74 MT-CO2 (0.53) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12252495-B2 Protein kinase B inhibitors ASTRAZENECA AB (SE) 2025-03-18 — — US disclosed
US-20240109902-A1 PROTEIN KINASE B INHIBITORS ASTRAZENECA AB (SE) 2024-04-04 — — US disclosed
US-11760760-B2 Protein kinase B inhibitors ASTRAZENECA AB (SE) 2023-09-19 — — US disclosed
US-20220220116-A1 PROTEIN KINASE B INHIBITORS ASTRAZENECA AB (SE) 2022-07-14 — — US disclosed
US-11236095-B2 Protein kinase B inhibitors ASTRAZENECA AB (SE) 2022-02-01 — — US disclosed
US-20200239483-A1 PROTEIN KINASE B INHIBITORS ASTRAZENECA AB (SE) 2020-07-30 — — US disclosed
US-10654855-B2 Protein kinase B inhibitors ASTRAZENECA AB (SE) 2020-05-19 — — US disclosed
US-20180312516-A1 Protein Kinase B Inhibitors ASTRAZENECA AB (SE) 2018-11-01 — — US disclosed
US-10059714-B2 Protein kinase B inhibitors ASTRAZENECA AB (SE) 2018-08-28 — — US disclosed
US-20170057969-A1 Novel Protein Kinase B Inhibitors - 060 ASTRAZENECA AB (SE) 2017-03-02 — — US disclosed
US-9492453-B2 Protein kinase B inhibitors ASTRAZENECA AB (SE) 2016-11-15 — — US disclosed
US-20150182531-A1 Novel Protein Kinase B Inhibitors - 060 ASTRAZENECA AB (SE) 2015-07-02 — — US disclosed
US-20120190679-A1 Novel Protein Kinase B Inhibitors - 060 ASTRAZENECA AB (SE) 2012-07-26 — — US disclosed
US-8101623-B2 Substituted pyrrolo[2,3-d]pyrimidine as a protein kinase B inhibitor ASTRAZENECA AB (SE) 2012-01-24 — — US disclosed
US-20090163524-A1 Novel Protein Kinase B Inhibitors - 060 ASTRAZENECA AB (SE) 2009-06-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12252495-B2 Protein kinase B inhibitors PRKAR2B, PRKCB, AKT1 GRIN2D 3204/4885GRIN3B 1914/4885GRIN1 1579/4885
US-20220220116-A1 PROTEIN KINASE B INHIBITORS PRKAR2B, PRKCB, AKT1 GRIN2D 3204/4885GRIN3B 1914/4885GRIN1 1579/4885
US-20180312516-A1 Protein Kinase B Inhibitors PRKAR2B, PRKCB, AKT1 GRIN2D 3204/4885GRIN3B 1914/4885GRIN1 1579/4885
US-10654855-B2 Protein kinase B inhibitors PRKAR2B, PRKCB, AKT1 GRIN2D 3204/4885GRIN3B 1914/4885GRIN1 1579/4885
US-20240109902-A1 PROTEIN KINASE B INHIBITORS PRKAR2B, PRKCB, AKT1 GRIN2D 3204/4885GRIN3B 1914/4885GRIN1 1579/4885
US-10059714-B2 Protein kinase B inhibitors PRKAR2B, PRKCB, AKT1 GRIN2D 3204/4885GRIN3B 1914/4885GRIN1 1579/4885
US-20090163524-A1 Novel Protein Kinase B Inhibitors - 060 PRKAR2B, PRKCB, MAP3K20 GRIN2D 3698/4885GRIN3B 2270/4885GRIN1 1713/4885
US-20170057969-A1 Novel Protein Kinase B Inhibitors - 060 PRKAR2B, PRKCB, MAP3K20 GRIN2D 3698/4885GRIN3B 2270/4885GRIN1 1713/4885
US-20200239483-A1 PROTEIN KINASE B INHIBITORS PRKAR2B, PRKCB, AKT1 GRIN2D 3204/4885GRIN3B 1914/4885GRIN1 1579/4885
US-20120190679-A1 Novel Protein Kinase B Inhibitors - 060 PRKAR2B, PRKCB, MAP3K20 GRIN2D 3698/4885GRIN3B 2270/4885GRIN1 1713/4885
US-11236095-B2 Protein kinase B inhibitors PRKAR2B, PRKCB, AKT1 GRIN2D 3204/4885GRIN3B 1914/4885GRIN1 1579/4885
US-20150182531-A1 Novel Protein Kinase B Inhibitors - 060 PRKAR2B, PRKCB, MAP3K20 GRIN2D 3698/4885GRIN3B 2270/4885GRIN1 1713/4885
US-11760760-B2 Protein kinase B inhibitors PRKAR2B, PRKCB, AKT1 GRIN2D 3204/4885GRIN3B 1914/4885GRIN1 1579/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.