Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | GABBR2 | O75899 | 3/20 | 0.44 |
| ▸ | GABBR1 | Q9UBS5 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1294954 | 1.00 | L3MBTL1 (0.46) | L3MBTL1CYP2C9MEN1CYP2D6CYP2C19 | |
| SCHEMBL3658423 | 1.00 | L3MBTL1 (0.46) | L3MBTL1CYP2C9MEN1CYP2D6CYP2C19 | |
| Hydrochloric Acid SCHEMBL391129 | 0.98 | L3MBTL1 (0.44) | L3MBTL1CYP2C9MEN1CYP2D6CYP2C19 | |
| Hydrochloric Acid SCHEMBL389435 | 0.98 | L3MBTL1 (0.44) | L3MBTL1CYP2C9MEN1CYP2D6CYP2C19 | |
| Hydrochloric Acid SCHEMBL391605 | 0.98 | L3MBTL1 (0.44) | L3MBTL1CYP2C9MEN1CYP2D6CYP2C19 | |
| SCHEMBL13802839 | 0.88 | RAB9A (0.56) | L3MBTL1MEN1KMT2AMAPTRAB9A | |
| SCHEMBL23673364 | 0.84 | ESR1 (0.46) | CYP2C9CYP2D6CYP2C19MAPTRAB9A | |
| SCHEMBL17167378 | 0.84 | ALDH1A1 (0.44) | L3MBTL1CYP2C19MAPTRAB9ALMNA | |
| SCHEMBL8298418 | 0.84 | MAPT (0.45) | CYP2D6CYP2C19MAPTRAB9ALMNA | |
| SCHEMBL5045992 | 0.84 | ALDH1A1 (0.44) | L3MBTL1CYP2C19MAPTRAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12252495-B2 | Protein kinase B inhibitors | ASTRAZENECA AB (SE) | 2025-03-18 | — | — | US | disclosed |
| US-20240109902-A1 | PROTEIN KINASE B INHIBITORS | ASTRAZENECA AB (SE) | 2024-04-04 | — | — | US | disclosed |
| US-11760760-B2 | Protein kinase B inhibitors | ASTRAZENECA AB (SE) | 2023-09-19 | — | — | US | disclosed |
| US-20220220116-A1 | PROTEIN KINASE B INHIBITORS | ASTRAZENECA AB (SE) | 2022-07-14 | — | — | US | disclosed |
| US-11236095-B2 | Protein kinase B inhibitors | ASTRAZENECA AB (SE) | 2022-02-01 | — | — | US | disclosed |
| EP-3712128-A1 | PHOTOCHEMICAL INTERMOLECULAR AMINATION METHOD | Fundació Institut Català d'Investigació Química (ICIQ) (ES) | 2020-09-23 | — | — | EP | disclosed |
| US-20200239483-A1 | PROTEIN KINASE B INHIBITORS | ASTRAZENECA AB (SE) | 2020-07-30 | — | — | US | disclosed |
| CN-107428720-B | Substituted aminotriazoles as inhibitors of acid mammalian chitinase | 昂科艾伦迪治疗法股份公司 | 2020-06-30 | — | — | CN | disclosed |
| US-10654855-B2 | Protein kinase B inhibitors | ASTRAZENECA AB (SE) | 2020-05-19 | — | — | US | disclosed |
| EP-3233832-B1 | SUBSTITUTED AMINO TRIAZOLES USEFUL AS ACIDIC MAMMALIAN CHITINASE INHIBITORS | ONCOARENDI THERAPEUTICS SA (PL) | 2019-11-20 | — | — | EP | disclosed |
| EP-2083011-A1 | PYRROLINE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR, PREPARATION METHODS AND USES THEREOF | Tian Jin Hemay Bio-Tech Co., Ltd. (CN) | 2009-07-29 | — | — | EP | disclosed |
| US-20090163524-A1 | Novel Protein Kinase B Inhibitors - 060 | ASTRAZENECA AB (SE) | 2009-06-25 | — | — | US | disclosed |
| WO-2009047563-A1 | PYRROLO [2, 3 -D] PYRIMIDIN DERIVATIVES AS PROTEIN KINASE B INHIBITORS | ASTRAZENECA AB (SE) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009033561-A1 | SUBSTITUTED 6-PHEYLNICOTINIC ACIDS AND THE USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-03-19 | — | — | WO | disclosed |
| CN-101186612-A | Pyrroline derivative capable of inhibiting cell to release tumor necrotic factor and its preparation and application | TIANJIN HEMEI BIOLOG TECHNOLOG (CN) | 2008-05-28 | — | — | CN | disclosed |
| US-7041667-B1 | CCR5 modulators | PFIZER, INC. (US) | 2006-05-09 | — | — | US | disclosed |
| EP-1028125-B1 | Dipeptide compounds having fungicidal activity and their agronomic use | ISAGRO RICERCA SRL (IT) | 2004-01-28 | — | — | EP | disclosed |
| US-6448228-B1 | FUNCTIONALIZED OLIGOPEPTIDE HAVING HIGH FUNGICIDAL ACTIVITY; ONE OR TWO ALIPHATIC AMINO ACIDS SUCH AS VALINE, LEUCINE AND ISOLEUCINE, CONJUGATED TO ONE OR TWO AROMATIC AMINO ACIDS, SUCH AS PHENYL-GLYCINE, PHENYLALANINE AND BETA-PHENYLALANINE | ISAGRO RICERCA S.R.L. (IT) | 2002-09-10 | — | — | US | disclosed |
| EP-1028125-A1 | Dipeptide compounds having fungicidal activity and their agronomic use | Isagro Ricerca S.r.l. (IT) | 2000-08-16 | — | — | EP | disclosed |
| EP-1013276-A1 | Aminoazacycloalkanes as CCR5 modulators | PFIZER INC. (US) | 2000-06-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12252495-B2 | Protein kinase B inhibitors | PRKAR2B, PRKCB, AKT1 | L3MBTL1 1246/4885CYP2C9 4111/4885MEN1 613/4885 |
| US-20220220116-A1 | PROTEIN KINASE B INHIBITORS | PRKAR2B, PRKCB, AKT1 | L3MBTL1 1246/4885CYP2C9 4111/4885MEN1 613/4885 |
| US-10654855-B2 | Protein kinase B inhibitors | PRKAR2B, PRKCB, AKT1 | L3MBTL1 1246/4885CYP2C9 4111/4885MEN1 613/4885 |
| US-20240109902-A1 | PROTEIN KINASE B INHIBITORS | PRKAR2B, PRKCB, AKT1 | L3MBTL1 1246/4885CYP2C9 4111/4885MEN1 613/4885 |
| US-20090163524-A1 | Novel Protein Kinase B Inhibitors - 060 | PRKAR2B, PRKCB, MAP3K20 | L3MBTL1 1269/4885CYP2C9 4553/4885MEN1 730/4885 |
| US-20200239483-A1 | PROTEIN KINASE B INHIBITORS | PRKAR2B, PRKCB, AKT1 | L3MBTL1 1246/4885CYP2C9 4111/4885MEN1 613/4885 |
| US-11236095-B2 | Protein kinase B inhibitors | PRKAR2B, PRKCB, AKT1 | L3MBTL1 1246/4885CYP2C9 4111/4885MEN1 613/4885 |
| US-11760760-B2 | Protein kinase B inhibitors | PRKAR2B, PRKCB, AKT1 | L3MBTL1 1246/4885CYP2C9 4111/4885MEN1 613/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.