Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | GAPDH | P04406 | 2/20 | 0.48 |
| ▸ | HSPA1A | P0DMV8 | 2/20 | 0.48 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.48 |
| ▸ | BLM | P54132 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.48 |
| ▸ | MIF | P14174 | 1/20 | 0.48 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.48 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.42 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.42 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.42 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.42 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.42 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.42 |
| ▸ | EDNRB | P24530 | 1/20 | 0.37 |
| ▸ | EDNRA | P25101 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14885415 | 0.87 | PRKAB2 (0.42) | KMT2AMEN1POLBGAPDHHSPA1A | |
| SCHEMBL28408792 | 0.83 | KMT2A (0.36) | KMT2AMEN1POLBGAPDHHSPA1A | |
| SCHEMBL1161682 | 0.81 | PRKAB2 (0.40) | KMT2AMEN1POLBGAPDHHSPA1A | |
| SCHEMBL4746812 | 0.80 | PRKAB2 (0.39) | TDP1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL3906697 | 0.80 | CDC25B (0.48) | KMT2AMEN1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL24456950 | 0.80 | PARP10 (0.43) | KMT2AMEN1POLBGAPDHHSPA1A | |
| SCHEMBL3986151 | 0.78 | EPHX2 (0.37) | KMT2AMEN1POLBGAPDHHSPA1A | |
| SCHEMBL15545052 | 0.77 | P2RX4 (0.39) | KMT2AMEN1POLBGAPDHHSPA1A | |
| SCHEMBL3749345 | 0.76 | HSPA1A (0.51) | HSPA1APTPN7TDP1CYP1A2MAPT | |
| SCHEMBL5800011 | 0.75 | ALDH1A1 (0.57) | HSPA1APTPN7TDP1PRKAB2PRKAG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2018371-A1 | PRIMARY AMINES AND DERIVATIVES THEREOF AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2009-01-28 | — | — | EP | claimed |
| WO-2007136703-A1 | PRIMARY AMINES AND DERIVATIVES THEREOF AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-11-29 | — | — | WO | claimed |