Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3914506 | 0.93 | KDM4E (0.47) | KDM4ELMNAALDH1A1MAPTGAA | |
| SCHEMBL3913456 | 0.84 | ALDH1A1 (0.59) | KDM4ELMNAALDH1A1MAPTGAA | |
| SCHEMBL377564 | 0.83 | ALDH1A1 (0.68) | ALDH1A1MAPTNPC1MAPK1HTT | |
| SCHEMBL3810128 | 0.83 | KDM4E (0.57) | KDM4ELMNAALDH1A1MAPTGAA | |
| SCHEMBL5030313 | 0.82 | GAA (0.48) | KDM4ELMNAGAAPOLBL3MBTL1 | |
| SCHEMBL3805407 | 0.79 | KDM4E (0.55) | KDM4ELMNAALDH1A1MAPTNPC1 | |
| SCHEMBL17048125 | 0.79 | KMT2A (0.47) | LMNAPOLBMAPK1HTTRAB9A | |
| SCHEMBL4597303 | 0.78 | LMNA (0.54) | KDM4ELMNAALDH1A1MAPTEPHX2 | |
| SCHEMBL3921754 | 0.78 | NOS2 (0.49) | KDM4ELMNAALDH1A1MAPTGAA | |
| SCHEMBL3913162 | 0.77 | MAPT (0.50) | KDM4ELMNAALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029538-A1 | BENZYLPIPERAZINE DERIVATIVES AS MOTILIN RECEPTOR ANTAGONISTS | Glaxo Group Limited (GB) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007144400-A1 | BENZYLPIPERAZINE DERIVATIVES AS MOTILIN RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2007-12-21 | — | — | WO | disclosed |