Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 5/20 | 0.40 |
| ▸ | CA2 | P00918 | 5/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | ELANE | P08246 | 2/20 | 0.40 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 3/20 | 0.39 |
| ▸ | IL1RN | P18510 | 1/20 | 0.39 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5222478 | 1.00 | ALDH1A1 (0.45) | ALDH1A1CTSLCTSSKMT2AMEN1 | |
| SCHEMBL8874165 | 1.00 | ALDH1A1 (0.45) | ALDH1A1CTSLCTSSKMT2AMEN1 | |
| SCHEMBL18256487 | 0.86 | ALDH1A1 (0.47) | ALDH1A1CTSLCTSSKMT2AMEN1 | |
| SCHEMBL3525448 | 0.86 | ALDH1A1 (0.47) | ALDH1A1CTSLCTSSKMT2AMEN1 | |
| SCHEMBL20276639 | 0.86 | ALDH1A1 (0.47) | ALDH1A1CTSLCTSSKMT2AMEN1 | |
| SCHEMBL7313485 | 0.81 | CTSK (0.43) | ALDH1A1CTSLCTSSCTSB | |
| SCHEMBL5870158 | 0.81 | CTSK (0.43) | ALDH1A1CTSLCTSSCTSB | |
| SCHEMBL8535402 | 0.81 | CTSB (0.47) | CTSLCTSSKMT2AMEN1CTSB | |
| SCHEMBL5555255 | 0.80 | CA12 (0.44) | ALDH1A1KMT2AMEN1TDP1MAPK1 | |
| SCHEMBL5133280 | 0.80 | CA12 (0.44) | ALDH1A1KMT2AMEN1TDP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090270417-A1 | Organic Compounds | NOVARTIS AG (CH) | 2009-10-29 | — | — | US | disclosed |
| EP-2032530-A1 | PYRROLIDINE COMPOUNDS AS RENIN INHIBITORS | Novartis AG (CH) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007144128-A1 | PYRROLIDINE COMPOUNDS AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2007-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270417-A1 | Organic Compounds | REN, ACE, OTC | ALDH1A1 136/4885CTSL 415/4885CTSS 269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.