Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 11/20 | 0.55 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.51 |
| ▸ | MAOA | P21397 | 4/20 | 0.49 |
| ▸ | MAOB | P27338 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1997471 | 0.82 | PTPN1 (0.61) | PTPN1PTPN2MAOAMAOBALDH1A1 | |
| SCHEMBL11880562 | 0.80 | PTPN1 (0.58) | PTPN1PTPN2MAOAMAOBALDH1A1 | |
| SCHEMBL28164923 | 0.79 | ALDH1A1 (0.49) | PTPN1PTPN2ALDH1A1CYP3A4POLB | |
| SCHEMBL31238271 | 0.79 | ALDH1A1 (0.49) | PTPN1PTPN2ALDH1A1CYP3A4POLB | |
| SCHEMBL4121887 | 0.78 | PTPN1 (0.45) | PTPN1MAOAMAOBPOLB | |
| SCHEMBL11878491 | 0.77 | PTPN1 (0.56) | PTPN1PTPN2MAOAMAOBALDH1A1 | |
| SCHEMBL23707495 | 0.74 | PTPN1 (0.67) | PTPN1PTPN2MAOAMAOBALDH1A1 | |
| SCHEMBL911098 | 0.74 | ALDH1A1 (0.68) | PTPN1PTPN2MAOAMAOBALDH1A1 | |
| SCHEMBL29952420 | 0.74 | ALDH1A1 (0.68) | PTPN1PTPN2MAOAMAOBALDH1A1 | |
| SCHEMBL29954451 | 0.72 | LMNA (0.60) | PTPN1PTPN2MAOAMAOBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090234023-A1 | SUBSTITUTED HYDROXYACETOPHENONE DERIVATIVES | RIEMSER ARZNEIMITTEL AG (DE) | 2009-09-17 | — | — | US | claimed |
| EP-1768945-A1 | SUBSTITUTED HYDROXYACETOPHENON DERIVATIVES | Riemser Arzneimittel AG (DE) | 2007-04-04 | — | — | EP | claimed |
| WO-2006003010-A1 | SUBSTITUTED HYDROXYACETOPHENON DERIVATIVES | RIEMSER ARZNEIMITTEL AG (DE) | 2006-01-12 | — | — | WO | claimed |
| US-20090234023-A1 | SUBSTITUTED HYDROXYACETOPHENONE DERIVATIVES | RIEMSER ARZNEIMITTEL AG (DE) | 2009-09-17 | — | — | US | disclosed |
| US-20090234023-A1 | SUBSTITUTED HYDROXYACETOPHENONE DERIVATIVES | RIEMSER ARZNEIMITTEL AG (DE) | 2009-09-17 | — | — | US | disclosed |
| US-20090234023-A1 | SUBSTITUTED HYDROXYACETOPHENONE DERIVATIVES | RIEMSER ARZNEIMITTEL AG (DE) | 2009-09-17 | — | — | US | disclosed |
| EP-1768945-B1 | SUBSTITUTED HYDROXYACETOPHENON DERIVATIVES | RIEMSER ARZNEIMITTEL AG (DE) | 2009-03-18 | — | — | EP | disclosed |
| EP-1768945-B1 | SUBSTITUTED HYDROXYACETOPHENON DERIVATIVES | RIEMSER ARZNEIMITTEL AG (DE) | 2009-03-18 | — | — | EP | disclosed |
| EP-1768945-A1 | SUBSTITUTED HYDROXYACETOPHENON DERIVATIVES | Riemser Arzneimittel AG (DE) | 2007-04-04 | — | — | EP | disclosed |
| WO-2006003010-A1 | SUBSTITUTED HYDROXYACETOPHENON DERIVATIVES | RIEMSER ARZNEIMITTEL AG (DE) | 2006-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090234023-A1 | SUBSTITUTED HYDROXYACETOPHENONE DERIVATIVES | GNPAT, HOGA1, NQO1 | PTPN1 2770/4885PTPN2 2327/4885MAOA 514/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.