Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | TTR | P02766 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL574999 | 0.85 | ALDH1A1 (0.52) | ERN1ALDH1A1TSHRTTRHSD17B10 | |
| SCHEMBL737479 | 0.83 | HSD17B10 (0.52) | ALDH1A1TSHRTTRHSD17B10CYP3A4 | |
| SCHEMBL28585231 | 0.81 | ERN1 (0.41) | ERN1ALDH1A1TTRCYP2C9KDM4E | |
| Phosphonic Acid SCHEMBL4093450 | 0.78 | HSD17B10 (0.42) | ALDH1A1TSHRTTRHSD17B10CYP3A4 | |
| SCHEMBL13243340 | 0.77 | ACHE (0.42) | ERN1KDM4ECASP6ACHE | |
| SCHEMBL3839778 | 0.77 | ACHE (0.42) | ERN1KDM4ECASP6ACHE | |
| SCHEMBL25370066 | 0.76 | ERN1 (0.39) | ERN1ALDH1A1HSD17B10RECQLKDM4E | |
| SCHEMBL30511599 | 0.76 | ERN1 (0.39) | ERN1ALDH1A1HSD17B10RECQLKDM4E | |
| SCHEMBL4420463 | 0.75 | ALDH1A1 (0.44) | ERN1ALDH1A1HSD17B10RECQLKDM4E | |
| SCHEMBL29459647 | 0.75 | XDH (0.50) | ERN1ALDH1A1TSHRTTRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029542-A2 | PRIMARY AMINES AS RENIN INHIBITORS | Actelion Pharmaceuticals Ltd. (CH) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007099509-A2 | PRIMARY AMINES AS RENIN INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2007-09-07 | — | — | WO | disclosed |
| WO-2006021401-A2 | BICYLONONENE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2006-03-02 | — | — | WO | disclosed |