Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 6/20 | 0.68 |
| ▸ | MC4R | P32245 | 1/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.53 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2792997 | 1.00 | CYP2D6 (0.68) | CYP2D6MC4ROPRM1OPRD1OPRK1 | |
| SCHEMBL8445058 | 0.86 | CYP2D6 (0.62) | CYP2D6MC4ROPRM1OPRD1OPRK1 | |
| SCHEMBL6706135 | 0.81 | CYP2D6 (1.00) | CYP2D6MC4ROPRM1OPRD1OPRK1 | |
| SCHEMBL7264542 | 0.81 | CYP2D6 (1.00) | CYP2D6MC4ROPRM1OPRD1OPRK1 | |
| SCHEMBL5355369 | 0.81 | CYP2D6 (0.74) | CYP2D6MC4ROPRM1OPRD1OPRK1 | |
| SCHEMBL16226061 | 0.81 | CYP2D6 (1.00) | CYP2D6MC4ROPRM1OPRD1OPRK1 | |
| SCHEMBL23850144 | 0.77 | CYP2D6 (0.83) | CYP2D6MC4ROPRM1OPRD1OPRK1 | |
| SCHEMBL16306975 | 0.77 | CYP2D6 (0.83) | CYP2D6MC4ROPRM1OPRD1OPRK1 | |
| SCHEMBL8983562 | 0.77 | CYP2D6 (0.83) | CYP2D6MC4ROPRM1OPRD1OPRK1 | |
| SCHEMBL8983627 | 0.77 | CYP2D6 (0.83) | CYP2D6MC4ROPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029537-B1 | BICYCLIC TETRAHYDROPYRROLE COMPOUNDS | ESTEVE LABOR DR (ES) | 2016-03-02 | — | — | EP | disclosed |
| US-9271959-B2 | Bicyclic tetrahydropyrrole compounds | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2016-03-01 | — | — | US | disclosed |
| US-20130072456-A1 | BICYCLIC TETRAHYDROPYRROLE COMPOUNDS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2013-03-21 | — | — | US | disclosed |
| US-8372990-B2 | Bicyclic tetrahydropyrrole compounds | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2013-02-12 | — | — | US | disclosed |
| US-20090318524-A1 | BICYCLIC TETRAHYDROPYRROLE COMPOUNDS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2009-12-24 | — | — | US | disclosed |
| US-20090306403-A1 | Production Process for Bicyclic Tetrahydropyrrole Compounds | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2009-12-10 | — | — | US | disclosed |
| EP-2076493-A1 | PRODUCTION PROCESS FOR BICYCLIC TETRAHYDROPYRROLE COMPOUNDS | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2009-07-08 | — | — | EP | disclosed |
| EP-2029537-A1 | BICYCLIC TETRAHYDROPYRROLE COMPOUNDS | Laboratorios del Dr. Esteve S.A. (ES) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007128459-A1 | BICYCLIC TETRAHYDROPYRROLE COMPOUNDS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-11-15 | — | — | WO | disclosed |
| WO-2007128457-A1 | PRODUCTION PROCESS FOR BICYCLIC TETRAHYDROPYRROLE COMPOUNDS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-11-15 | — | — | WO | disclosed |
| EP-1849772-A1 | Bicyclic tetrahydropyrrole compounds | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-10-31 | — | — | EP | disclosed |
| EP-1849770-A1 | Production process for bicyclic tetrahydropyrrole compounds | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-10-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130072456-A1 | BICYCLIC TETRAHYDROPYRROLE COMPOUNDS | CYP11B2, CYP11B1, SDHA | CYP2D6 17/4885MC4R 124/4885OPRM1 99/4885 |
| US-20090306403-A1 | Production Process for Bicyclic Tetrahydropyrrole Compounds | DHPS, PAH, CYP2C19 | CYP2D6 7/4885MC4R 521/4885OPRM1 1977/4885 |
| US-20090318524-A1 | BICYCLIC TETRAHYDROPYRROLE COMPOUNDS | CYP11B2, CYP11B1, SDHA | CYP2D6 17/4885MC4R 124/4885OPRM1 99/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.