Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL858572 | 0.80 | MEN1 (0.48) | CALM1TAAR1HTR2CLTB4RALDH1A1 | |
| SCHEMBL3921691 | 0.79 | AR (0.42) | TAAR1HTR2CALDH1A1HPGDMAPK1 | |
| SCHEMBL9003043 | 0.76 | NPC1 (0.44) | CALM1BCL2BCL2L1ALDH1A1KDM4E | |
| SCHEMBL5477397 | 0.76 | CALM1 (0.46) | CALM1BCL2BCL2L1TAAR1ALDH1A1 | |
| SCHEMBL3913574 | 0.76 | LMNA (0.53) | HTR2CALDH1A1HPGDLMNATSHR | |
| SCHEMBL15170453 | 0.75 | P2RX3 (0.42) | ALDH1A1LMNATSHRPARP1 | |
| SCHEMBL16274651 | 0.74 | SMN1; SMN2 (0.51) | ALDH1A1HPGDKDM4ELMNAMAPK1 | |
| SCHEMBL28384228 | 0.72 | TAAR1 (0.43) | CALM1TAAR1HTR2CLTB4RALDH1A1 | |
| SCHEMBL31457102 | 0.72 | CALM1 (0.41) | CALM1TAAR1HTR2CLTB4RHPGD | |
| SCHEMBL29044391 | 0.72 | CALM1 (0.41) | CALM1TAAR1HTR2CLTB4RHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110053931-A1 | QUINOLINE COMPOUNDS AND METHODS OF USE | GAUDINO JOHN | 2011-03-03 | — | — | US | disclosed |
| CN-101528702-A | Quinoline compounds and methods of use | ARRAY BIOPHARMA INC (US) | 2009-09-09 | — | — | CN | disclosed |
| EP-2032538-A2 | QUINOLINE COMPOUNDS AND METHODS OF USE | Array Biopharma, Inc. (US) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007146824-A2 | QUINOLINE COMPOUNDS AND METHODS OF USE | ARRAY BIOPHARMA INC. (US) | 2007-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110053931-A1 | QUINOLINE COMPOUNDS AND METHODS OF USE | TK1, ABL1, ROR1 | CALM1 862/4885BCL2 1507/4885BCL2L1 2096/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.