Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 4/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.51 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28004243 | 0.85 | CYP19A1 (0.68) | CYP19A1LMNAMAPTALDH1A1KMT2A | |
| SCHEMBL28113721 | 0.85 | CA12 (0.63) | CYP19A1LMNASLC12A2SLC12A5ALDH1A1 | |
| SCHEMBL3566649 | 0.82 | CYP19A1 (0.52) | CYP19A1LMNASLC12A2SLC12A5ALDH1A1 | |
| SCHEMBL3924460 | 0.81 | CYP19A1 (0.67) | CYP19A1LMNASLC12A2SLC12A5MAPT | |
| SCHEMBL13973371 | 0.81 | CYP19A1 (0.51) | CYP19A1LMNASLC12A2SLC12A5MAPT | |
| SCHEMBL13959225 | 0.80 | LMNA (0.53) | CYP19A1LMNASLC12A2SLC12A5ALDH1A1 | |
| SCHEMBL19334506 | 0.79 | ALDH1A1 (0.61) | LMNAALDH1A1KMT2A | |
| SCHEMBL5960052 | 0.76 | CA12 (0.71) | CYP19A1LMNAALDH1A1KMT2A | |
| SCHEMBL20946457 | 0.76 | CYP19A1 (0.69) | CYP19A1MAPTALDH1A1KMT2A | |
| SCHEMBL3925035 | 0.76 | CA12 (0.71) | CYP19A1LMNAALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035372-A1 | MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2008005338-A1 | MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-01-10 | — | — | WO | disclosed |