Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | TOP1 | P11387 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | PTPRC | P08575 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6509937 | 0.80 | CLK4 (0.41) | ALDH1A1HSD17B10GRM5MAPK1MAP4K4 | |
| SCHEMBL1008743 | 0.80 | ALOX15 (0.44) | TOP1ALDH1A1HSD17B10HTTPTGS1 | |
| SCHEMBL7024820 | 0.80 | ALDH1A1 (0.42) | CYP2A6TOP1ALDH1A1HSD17B10HTT | |
| SCHEMBL29429073 | 0.77 | ALDH1A1 (0.48) | ALDH1A1HSD17B10GRM5HPGDCTSL | |
| SCHEMBL28035850 | 0.74 | SMARCA2 (0.36) | CYP2A6ALDH1A1MAPK1MAP4K4CHEK1 | |
| SCHEMBL12811658 | 0.74 | GRM5 (0.41) | GRM5CTSLPTPRCCTSSPTPN13 | |
| SCHEMBL27933452 | 0.74 | KDM4E (0.45) | ALDH1A1HSD17B10HTTHPGDMAPK1 | |
| SCHEMBL27937121 | 0.74 | CYP2A6 (0.46) | CYP2A6ALDH1A1HSD17B10HTTPTGS2 | |
| SCHEMBL8915138 | 0.73 | ALOX15 (0.37) | PTGS1PTGS2CHEK1GSK3B | |
| SCHEMBL15570377 | 0.72 | ALDH1A1 (0.46) | CYP2A6TOP1ALDH1A1HSD17B10HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023122212-A3 | SUBSTITUTED PHENYL ETHYNYL PYRIDINE CARBOXAMIDES AS POTENT INHIBITORS OF SARS VIRUS | SOUTHERN RESEARCH INSTITUTE (US) | 2023-08-03 | — | — | WO | disclosed |
| WO-2023122212-A2 | SUBSTITUTED PHENYL ETHYNYL PYRIDINE CARBOXAMIDES AS POTENT INHIBITORS OF SARS VIRUS | SOUTHERN RESEARCH INSTITUTE (US) | 2023-06-29 | — | — | WO | disclosed |
| WO-2023122212-A2 | SUBSTITUTED PHENYL ETHYNYL PYRIDINE CARBOXAMIDES AS POTENT INHIBITORS OF SARS VIRUS | SOUTHERN RESEARCH INSTITUTE (US) | 2023-06-29 | — | — | WO | disclosed |
| EP-2028180-A1 | Novel aminopyridine derivatives as mGluR5 antagonists | ADDEX Pharma S.A. (CH) | 2009-02-25 | — | — | EP | disclosed |
| EP-1603877-B1 | NOVEL AMINOPYRIDINE DERIVATIVES AS mGIuR5 ANTAGONISTS | ADDEX PHARMA SA (CH) | 2008-11-26 | — | — | EP | disclosed |
| US-20080004316-A1 | Novel aminopyridine derivatives as mGluR5 antagonists | ADDEX PHARMACEUTICALS SA (CH) | 2008-01-03 | — | — | US | disclosed |
| US-7205411-B2 | Aminopyridine derivatives as mGluR5 antagonists | ADDEX PHARMACEUTICALS SA (CH) | 2007-04-17 | — | — | US | disclosed |
| US-20060030601-A1 | Novel aminopyridine derivatives as mGluR5 antagonists | ADDEX PHARMACEUTICALS SA (CH) | 2006-02-09 | — | — | US | disclosed |
| EP-1603877-A1 | NOVEL AMINOPYRIDINE DERIVATIVES AS mGIuR5 ANTAGONISTS | Addex Pharmaceuticals SA (CH) | 2005-12-14 | — | — | EP | disclosed |
| WO-2004078728-A1 | NOVEL AMINOPYRIDINE DERIVATIVES AS mGIuR5 ANTAGONISTS | ADDEX PHARMACEUTICALS SA (CH) | 2004-09-16 | — | — | WO | disclosed |
| US-5639753-A | CONTROLLING INSECTS IN AGRICULTURE CROPS | FMC CORPORATION (US) | 1997-06-17 | — | — | US | disclosed |
| US-5532367-A | LARVICIDES | FMC CORPORATION (US) | 1996-07-02 | — | — | US | disclosed |
| US-5521190-A | USEFUL AGAINST TOBACCO BUDWORM | FMC CORPORATION (US) | 1996-05-28 | — | — | US | disclosed |
| WO-1994027439-A1 | INSECTICIDAL PTERIDINES AND 8-DEAZAPTERIDINES | FMC CORPORATION (US) | 1994-12-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004316-A1 | Novel aminopyridine derivatives as mGluR5 antagonists | GRM5, GRM6, GRM2 | CYP2A6 1716/4885TOP1 4720/4885ALDH1A1 3199/4885 |
| US-20060030601-A1 | Novel aminopyridine derivatives as mGluR5 antagonists | GRM5, GRM6, GRM2 | CYP2A6 1716/4885TOP1 4720/4885ALDH1A1 3199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.