Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 4/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | APLNR | P35414 | 2/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30323273 | 0.78 | BRD4 (0.49) | BRD4KDM4EALDH1A1SMN1; SMN2ADRA2C | |
| SCHEMBL21508055 | 0.78 | OPRD1 (0.47) | BRD4OPRK1ALDH1A1SMN1; SMN2MAOB | |
| SCHEMBL21921488 | 0.76 | MAOB (0.40) | BRD4KDM4EALDH1A1SMN1; SMN2MAOB | |
| SCHEMBL11555464 | 0.75 | BRD4 (0.54) | BRD4ADRA2CMAOBCREBBPPGR | |
| SCHEMBL11575773 | 0.75 | KDM4E (0.54) | BRD4OPRK1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL996127 | 0.74 | ADRA2C (0.64) | ADRA2CMAOBCLK4CHEK1CYP1A2 | |
| SCHEMBL8231701 | 0.73 | HTR7 (0.41) | BRD4KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL11552593 | 0.72 | BRD4 (0.51) | BRD4OPRM1OPRK1KDM4EALDH1A1 | |
| SCHEMBL17748926 | 0.72 | BRD4 (1.00) | BRD4CREBBP | |
| SCHEMBL31272452 | 0.71 | ADRA2C (0.60) | ADRA2CMAOBCLK4CHEK1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029582-A1 | ISOINDOLIN-1-ONE-, ISOINDOLIN-3-ONE- AND ISOINDOLIN-1,3-DIONE-DERIVATIVES AND USE THEREOF | Bayer HealthCare AG (DE) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007137790-A1 | ISOINDOLIN-1-ONE-, ISOINDOLIN-3-ONE- AND ISOINDOLIN-1,3-DIONE-DERIVATIVES AND USE THEREOF | BAYER HEALTHCARE AG (DE) | 2007-12-06 | — | — | WO | disclosed |