Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.43 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13170238 | 0.86 | ALDH1A1 (0.64) | P2RX7TP53ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL30259908 | 0.86 | ALDH1A1 (0.64) | P2RX7TP53ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL935059 | 0.84 | HPGD (0.54) | P2RX7TP53ALDH1A1HPGDKMT2A | |
| SCHEMBL5670334 | 0.82 | P2RX7 (0.52) | P2RX7TP53ALDH1A1HPGDKMT2A | |
| SCHEMBL2267520 | 0.81 | MCL1 (0.54) | P2RX7TP53ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL12366173 | 0.81 | P2RX7 (0.52) | P2RX7TP53ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL27847330 | 0.81 | P2RX7 (0.51) | P2RX7TP53ALDH1A1HPGDKMT2A | |
| SCHEMBL10150926 | 0.78 | HTT (0.50) | ALDH1A1HPGDKMT2AMEN1NPC1 | |
| SCHEMBL16108558 | 0.77 | ALDH1A1 (0.49) | P2RX7TP53ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8765952 | 0.77 | GAA (0.51) | P2RX7TP53ALDH1A1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029542-A2 | PRIMARY AMINES AS RENIN INHIBITORS | Actelion Pharmaceuticals Ltd. (CH) | 2009-03-04 | — | — | EP | claimed |
| WO-2007099509-A2 | PRIMARY AMINES AS RENIN INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2007-09-07 | — | — | WO | claimed |
| EP-2029542-A2 | PRIMARY AMINES AS RENIN INHIBITORS | Actelion Pharmaceuticals Ltd. (CH) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007099509-A2 | PRIMARY AMINES AS RENIN INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2007-09-07 | — | — | WO | disclosed |