SCHEMBL8765952

SCHEMBL8765952

C=CC(=O)NCc1cccc(C)c1C

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.51
KMT2A Q03164 1/20 0.51
P2RX7 Q99572 2/20 0.48
TGM2 P21980 1/20 0.45
TP53 P04637 1/20 0.44
HPGD P15428 3/20 0.44
ALDH1A1 P00352 3/20 0.44
KDM4C Q9H3R0 1/20 0.43
HTT P42858 1/20 0.41
CD38 P28907 1/20 0.40
EGFR P00533 1/20 0.40
BTK Q06187 1/20 0.40
KDM4E B2RXH2 1/20 0.40
CDK1 P06493 1/20 0.40
PIM1 P11309 1/20 0.40
MAPKAPK2 P49137 1/20 0.40
GSK3A P49840 1/20 0.40
PLK1 P53350 1/20 0.40
AURKB Q96GD4 1/20 0.40
ESR1 P03372 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5082541 0.87 KMT2A (0.67) GAAKMT2ATGM2HPGDALDH1A1
SCHEMBL935059 0.81 HPGD (0.54) GAAKMT2AP2RX7TP53HPGD
SCHEMBL59858 0.81 TGM2 (0.55) GAAKMT2ATGM2HPGDALDH1A1
SCHEMBL5670334 0.80 P2RX7 (0.52) GAAKMT2AP2RX7TP53HPGD
SCHEMBL27847330 0.78 P2RX7 (0.51) GAAKMT2AP2RX7TP53HPGD
SCHEMBL3921086 0.77 P2RX7 (0.57) GAAKMT2AP2RX7TP53HPGD
SCHEMBL410698 0.75 TSHR (0.52) GAAKMT2ATGM2ALDH1A1KDM4E
SCHEMBL2449430 0.75 TGM2 (0.53) GAAKMT2ATGM2HPGDALDH1A1
SCHEMBL24112688 0.74 TGM2 (0.45) GAAKMT2ATGM2HPGDALDH1A1
SCHEMBL16634646 0.74 TGM2 (0.45) GAAKMT2ATGM2HPGDALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0505972-B1 Process for producing styrenic copolymer IDEMITSU KOSAN CO (JP) 1997-06-11 EP disclosed
EP-0490269-B1 Graft copolymer and process for producing the same IDEMITSU KOSAN CO (JP) 1996-02-28 EP disclosed
US-5250629-A Graft polymerization of styrene and ethylenically unsaturated monomer using transition metal catalysts, organoaluminum compounds; films, packaging, automobile parts IDEMITSU KOSAN CO., LTD. (JP) 1993-10-05 US disclosed
EP-0505972-A2 Process for producing styrenic copolymer IDEMITSU KOSAN COMPANY LIMITED (JP) 1992-09-30 EP disclosed
EP-0490269-A1 Graft copolymer and process for producing the same IDEMITSU KOSAN COMPANY LIMITED (JP) 1992-06-17 EP disclosed