Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12366090 | 0.88 | ALDH1A1 (0.57) | P2RX7TP53ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3921086 | 0.81 | P2RX7 (0.57) | P2RX7TP53ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL935059 | 0.79 | HPGD (0.54) | P2RX7TP53ALDH1A1HPGDKMT2A | |
| SCHEMBL5670334 | 0.77 | P2RX7 (0.52) | P2RX7TP53ALDH1A1HPGDKMT2A | |
| SCHEMBL12366130 | 0.76 | NPC1 (0.56) | P2RX7ALDH1A1SMN1; SMN2KMT2APOLB | |
| SCHEMBL12366179 | 0.76 | P2RX7 (0.46) | P2RX7ALDH1A1HPGDSMN1; SMN2KMT2A | |
| SCHEMBL2267520 | 0.76 | MCL1 (0.54) | P2RX7TP53ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL12366175 | 0.76 | NPC1 (0.56) | P2RX7TP53ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL12366196 | 0.76 | KMT2A (0.58) | P2RX7HPGDSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL27847330 | 0.76 | P2RX7 (0.51) | P2RX7TP53ALDH1A1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998986-B2 | Heterocyclic compounds, in particular N-substituted pyridones for modulating the activity of nuclear receptors | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |