Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 8/20 | 1.00 |
| ▸ | HPGD | P15428 | 7/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.81 |
| ▸ | RAB9A | P51151 | 6/20 | 0.81 |
| ▸ | NPC1 | O15118 | 5/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.81 |
| ▸ | POLB | P06746 | 2/20 | 0.81 |
| ▸ | KIF11 | P52732 | 4/20 | 0.75 |
| ▸ | MAPT | P10636 | 4/20 | 0.69 |
| ▸ | LMNA | P02545 | 3/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | TNF | P01375 | 4/20 | 0.67 |
| ▸ | NOD1 | Q9Y239 | 4/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3922433 | 0.90 | MEN1 (0.82) | MEN1KMT2AHPGDALDH1A1RAB9A | |
| SCHEMBL15281362 | 0.83 | KMT2A (0.71) | MEN1KMT2AHPGDALDH1A1RAB9A | |
| SCHEMBL3918724 | 0.82 | HPGD (1.00) | MEN1KMT2AHPGDALDH1A1RAB9A | |
| SCHEMBL21247231 | 0.80 | MAPT (0.76) | MEN1KMT2AALDH1A1RAB9ANPC1 | |
| SCHEMBL7901259 | 0.78 | TP53 (0.81) | MEN1KMT2AHPGDRAB9ANPC1 | |
| SCHEMBL23752237 | 0.78 | KIF11 (1.00) | MEN1KMT2AHPGDALDH1A1RAB9A | |
| SCHEMBL21260633 | 0.76 | TNF (0.62) | MEN1KMT2AHPGDALDH1A1RAB9A | |
| SCHEMBL2182372 | 0.76 | TP53 (0.80) | MEN1KMT2AALDH1A1RAB9ANPC1 | |
| SCHEMBL12469953 | 0.73 | MAPT (0.76) | MEN1KMT2AALDH1A1RAB9ANPC1 | |
| SCHEMBL12443131 | 0.73 | TP53 (0.80) | MEN1KMT2AHPGDALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090298842-A1 | Novel therapeutic targets for the treatment of mycobacterial infections and compounds useful therefor | PATO JANOS | 2009-12-03 | — | — | US | claimed |
| US-20090018149-A1 | 4,5,6,7-tetrahydrobenzo[b]thiophene derivatives and methods for medical intervention against mycobacterial infections | AXXIMA PHARMACEUTICALS AG (DE) | 2009-01-15 | — | — | US | claimed |
| US-20040171603-A1 | Novel therapeutic targets for the treatment of mycobacterial infections and compounds useful therefor | VICHEM CHEMIE KFT (HU) | 2004-09-02 | — | — | US | claimed |
| US-20090298842-A1 | Novel therapeutic targets for the treatment of mycobacterial infections and compounds useful therefor | PATO JANOS | 2009-12-03 | — | — | US | disclosed |
| US-20090018149-A1 | 4,5,6,7-tetrahydrobenzo[b]thiophene derivatives and methods for medical intervention against mycobacterial infections | AXXIMA PHARMACEUTICALS AG (DE) | 2009-01-15 | — | — | US | disclosed |
| US-20040171603-A1 | Novel therapeutic targets for the treatment of mycobacterial infections and compounds useful therefor | VICHEM CHEMIE KFT (HU) | 2004-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298842-A1 | Novel therapeutic targets for the treatment of mycobacterial infections and compounds useful therefor | PKLR, MASTL, BPGM | MEN1 2985/4885KMT2A 3792/4885HPGD 964/4885 |
| US-20040171603-A1 | Novel therapeutic targets for the treatment of mycobacterial infections and compounds useful therefor | PKLR, PKN1, PKMYT1 | MEN1 2405/4885KMT2A 3324/4885HPGD 852/4885 |
| US-20090018149-A1 | 4,5,6,7-tetrahydrobenzo[b]thiophene derivatives and methods for medical intervention against mycobacterial infections | STK4, SBK3, STK17B | MEN1 4022/4885KMT2A 4066/4885HPGD 2459/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.