Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | UBE2N | P61088 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | FSCN1 | Q16658 | 4/20 | 0.45 |
| ▸ | SCD | O00767 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | DBH | P09172 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3914606 | 0.88 | GRM2 (0.44) | SMN1; SMN2MAPK1LMNAHTTUBE2N | |
| SCHEMBL3111412 | 0.85 | CYP11B1 (0.51) | SMN1; SMN2MAPK1LMNAHTTKMT2A | |
| SCHEMBL3912725 | 0.84 | SCD (0.48) | SMN1; SMN2MAPK1SCD | |
| SCHEMBL3921634 | 0.82 | EGLN1 (0.53) | SMN1; SMN2MAPK1LMNAHTTUBE2N | |
| SCHEMBL3914923 | 0.81 | CYP11B1 (0.54) | SMN1; SMN2LMNAHTTKMT2ACYP11B1 | |
| SCHEMBL3911396 | 0.81 | TP53 (0.53) | SMN1; SMN2LMNAHTTKMT2ATSHR | |
| SCHEMBL3912721 | 0.80 | CYP11B1 (0.54) | SMN1; SMN2LMNACYP11B1CYP11B2 | |
| SCHEMBL3915564 | 0.80 | LMNA (0.45) | LMNAHTTKMT2AFSCN1SCD | |
| SCHEMBL3913086 | 0.77 | ABCC8 (0.49) | SMN1; SMN2MAPK1HTTKMT2ACYP11B1 | |
| SCHEMBL2400441 | 0.77 | CYP11B2 (0.56) | LMNACYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110053931-A1 | QUINOLINE COMPOUNDS AND METHODS OF USE | GAUDINO JOHN | 2011-03-03 | — | — | US | disclosed |
| EP-2032538-A2 | QUINOLINE COMPOUNDS AND METHODS OF USE | Array Biopharma, Inc. (US) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007146824-A2 | QUINOLINE COMPOUNDS AND METHODS OF USE | ARRAY BIOPHARMA INC. (US) | 2007-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110053931-A1 | QUINOLINE COMPOUNDS AND METHODS OF USE | TK1, ABL1, ROR1 | SMN1; SMN2 1817/4885MAPK1 83/4885LMNA 1139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.