Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.69 |
| ▸ | THRB | P10828 | 6/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | HTT | P42858 | 2/20 | 0.69 |
| ▸ | MAPT | P10636 | 8/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.65 |
| ▸ | MEN1 | O00255 | 4/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | RECQL | P46063 | 1/20 | 0.62 |
| ▸ | ATM | Q13315 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 3/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3922155 | 1.00 | ALDH1A1 (0.69) | ALDH1A1THRBLMNAHTTMAPT | |
| SCHEMBL12445224 | 0.88 | MAPK1 (0.71) | ALDH1A1THRBLMNAHTTMAPT | |
| SCHEMBL3472335 | 0.82 | ALDH1A1 (1.00) | ALDH1A1THRBLMNAHTTMAPT | |
| SCHEMBL3472339 | 0.82 | ALDH1A1 (1.00) | ALDH1A1THRBLMNAHTTMAPT | |
| SCHEMBL10406531 | 0.80 | KMT2A (0.75) | ALDH1A1LMNAMAPTKMT2ANPSR1 | |
| SCHEMBL11356974 | 0.80 | ALDH1A1 (0.75) | ALDH1A1LMNAMAPTKMT2ANPSR1 | |
| SCHEMBL18542006 | 0.79 | MAPK1 (1.00) | ALDH1A1LMNAMAPTKMT2ANPSR1 | |
| SCHEMBL8288712 | 0.78 | MAPT (0.68) | ALDH1A1THRBHTTMAPTSMN1; SMN2 | |
| SCHEMBL10612470 | 0.77 | MAPK1 (0.71) | ALDH1A1LMNAMAPTKMT2ANPSR1 | |
| SCHEMBL1622930 | 0.76 | MAPK1 (0.78) | ALDH1A1LMNAMAPTKMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7563813-B2 | Iminothiazolidinone derivatives as SFRP-1 antagonists | WYETH (US) | 2009-07-21 | — | — | US | disclosed |
| US-20060270720-A1 | Iminothiazolidinone derivatives as SFRP-1 antagonists | WYETH (US) | 2006-11-30 | — | — | US | disclosed |
| WO-2006124887-A1 | IMINOTHIAZOLIDINONE DERIVATIVES AS SFRP-1 ANTAGONISTS | WYETH (US) | 2006-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060270720-A1 | Iminothiazolidinone derivatives as SFRP-1 antagonists | SFRP1, FZD7, DKK1 | ALDH1A1 683/4885THRB 1943/4885LMNA 4353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.